Animal models of Parkinson's disease progression
GE Meredith, PK Sonsalla, MF Chesselet - Acta neuropathologica, 2008 - Springer
Parkinson’s disease (PD) is a progressive neurodegenerative disorder whose etiology is not
understood. This disease occurs both sporadically and through inheritance of single genes, …
understood. This disease occurs both sporadically and through inheritance of single genes, …
Adenosine A2A receptors and brain injury: broad spectrum of neuroprotection, multifaceted actions and “fine tuning” modulation
This review summarizes recent developments that have contributed to understand how
adenosine receptors, particularly A 2A receptors, modulate brain injury in various animal models …
adenosine receptors, particularly A 2A receptors, modulate brain injury in various animal models …
[PDF][PDF] Neuroprotection by caffeine and A (2A) adenosine receptor inactivation in a model of Parkinson's disease.
…, R Staal, YH Xu, M Beilstein, PK Sonsalla… - The Journal of …, 2001 - Soc Neuroscience
Recent epidemiological studies have established an association between the common
consumption of coffee or other caffeinated beverages and a reduced risk of developing Parkinson…
consumption of coffee or other caffeinated beverages and a reduced risk of developing Parkinson…
Role of glutamate in neurodegeneration of dopamine neurons in several animal models of parkinsonism
PK Sonsalla, DS Albers, GD Zeevalk - Amino acids, 1998 - Springer
Although controversial, studies with methamphetamine and MPTP suggest a link between
glutamate-mediated excitotoxicity and degeneration of dopamine cells. Both compounds are …
glutamate-mediated excitotoxicity and degeneration of dopamine cells. Both compounds are …
Role for excitatory amino acids in methamphetamine-induced nigrostriatal dopaminergic toxicity
PK Sonsalla, WJ Nicklas, RE Heikkila - Science, 1989 - science.org
The systemic administration of either methamphetamine or 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
(MPTP) to experimental animals produces degenerative changes in …
(MPTP) to experimental animals produces degenerative changes in …
Midbrain dopaminergic cell loss in Parkinson's disease and MPTP-induced parkinsonism: sparing of calbindin-D28k-containing cells.
DC German, KF Manaye, PK Sonsalla… - Annals of the New York …, 1992 - europepmc.org
Computer imaging and immunohistochemical staining techniques were used to determine
which midbrain dopaminergic (DA) cells are spared in Parkinson's disease (PD), and in …
which midbrain dopaminergic (DA) cells are spared in Parkinson's disease (PD), and in …
[PDF][PDF] Role of dopamine in the neurotoxic effects of methamphetamine.
CJ Schmidt, JK Ritter, PK Sonsalla, GR Hanson… - … of Pharmacology and …, 1985 - Citeseer
Multiple administrations of high doses of methamphetamine to rats cause long-term
depression of both dopamine and serotonin synthesis. Coadministration of the catecholamine …
depression of both dopamine and serotonin synthesis. Coadministration of the catecholamine …
[PDF][PDF] Methamphetamine-induced hyperthermia and dopaminergic neurotoxicity in mice: pharmacological profile of protective and nonprotective agents.
DS Albers, PK Sonsalla - Journal of Pharmacology and Experimental …, 1995 - Citeseer
Neurotoxic doses of methamphetamine(METH) can cause hyperthermia in experimental
animals. Damage sustained to dopaminergic nerve terminals by this stimulant can be reduced …
animals. Damage sustained to dopaminergic nerve terminals by this stimulant can be reduced …
Enhanced phosphatase activity attenuates α-synucleinopathy in a mouse model
…, E Junn, JY Im, H Grosso, PK Sonsalla… - Journal of …, 2011 - Soc Neuroscience
α-Synuclein (α-Syn) is a key protein that accumulates as hyperphosphorylated aggregates
in pathologic hallmark features of Parkinson's disease (PD) and other neurodegenerative …
in pathologic hallmark features of Parkinson's disease (PD) and other neurodegenerative …
The influence of dose and dosing interval on MPTP-induced dopaminergic neurotoxicity in mice
PK Sonsalla, RE Heikkila - European journal of pharmacology, 1986 - Elsevier
The effects of different dosing paradigms for the administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
(MPTP) were investigated in C57-black and CF-W albino mice. Several …
(MPTP) were investigated in C57-black and CF-W albino mice. Several …