BACKGROUND & AIMS: Gastric cancer evolves in the setting of a pathologic mucosal milieu
characterized by both loss of acid-secreting parietal cells and mucous cell metaplasias. …

Structural modifications requiring novel synthetic chemistry were made to the morpholine
acetal human neurokinin-1 (hNK-1) receptor antagonist 4, and this resulted in the discovery of 2…

The anti-emetic profile of the novel brain penetrant tachykinin NK 1 receptor antagonist MK–0869
(L–754,030) 2–(R)–(1–(R)–(3,5–bis(trifluoromethyl)phenylethoxy)–3–(S)–(4–fluoro)…

Objectives Spasmolytic polypeptide-expressing metaplasia (SPEM) develops as a
preneoplastic lesion in the stomachs of mice and humans after parietal cell loss. To identify the …

The regioselective dibenzylphosphorylation of 2 followed by catalytic reduction in the
presence of N-methyl-d-glucamine afforded 2-(S)-(1-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(…

(2S)-2-(3-Chlorophenyl)-1-[N-(methyl)-N-(phenylsulfonyl)amino]-4-[spiro(2,3-dihydrobenzthiophene-3,4′-piperidin-1′-yl)]butane
S-oxide (1b) has been identified as a potent CCR5 …

Several laboratories, including our own, have reported the synthesis and activity of certain
low relative molecular mass inhibitors of mammalian serine proteases 1–4 , especially human …

Background Alpha-1-antitrypsin (A1AT) deficiency is the only recognised genetic risk factor
for chronic obstructive pulmonary disease (COPD), a leading cause of morbidity and …

… Finke a , Bryan Oates a , Malcolm MacCoss a , Sander G. Mills a , Lorraine Malkowitz b ,
Sandra L. Gould b , Julie A. … Feng, CC Broder, PE Kennedy, EA Berger … Dorn Jr., PE …

Replacement of the large hydantoin-indole moiety from our previous work with a variety of
smaller heterocyclic analogues gave rise to potent CCR5 antagonists having binding affinity …