The Concise Guide to PHARMACOLOGY 2021/22: G protein‐coupled receptors
…, D Thal, W Thomas, PB Timmermans… - British journal of …, 2021 - Wiley Online Library
The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial
publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key …
publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key …
Identification of angiotensin II receptor subtypes
…, RR Wexler, AL Johnson, PB Timmermans - Biochemical and …, 1989 - Elsevier
We have demonstrated the existence of two distinct subtypes of the angiotensin II receptor
in the rat adrenal gland using radioligand binding and tissue section autoradiography. The …
in the rat adrenal gland using radioligand binding and tissue section autoradiography. The …
The Concise Guide to PHARMACOLOGY 2019/20: G protein‐coupled receptors
…, V Tan, W Thomas, PB Timmermans… - British journal of …, 2019 - Wiley Online Library
The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial
publications. The Concise Guide provides concise overviews of the key properties of nearly 1800 …
publications. The Concise Guide provides concise overviews of the key properties of nearly 1800 …
Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy
…, RD Smith, PB Timmermans - Journal of Medicinal …, 1996 - ACS Publications
The renin-angiotensin system (RAS) is recognized as a key element in blood pressure
regulation and electrolyte/fluid homeostasis. 1 As outlined in Figure 1, the RAS constitutes a …
regulation and electrolyte/fluid homeostasis. 1 As outlined in Figure 1, the RAS constitutes a …
Nomenclature for angiotensin receptors. A report of the Nomenclature Committee of the Council for High Blood Pressure Research.
…, MJ Peach, DG Taylor Jr, PB Timmermans - …, 1991 - Am Heart Assoc
The peptide hormone angiotensin II is produced by the sequential processing of the
prohormone angiotensinogen by renin and angiotensin I converting enzyme. Angiotensin II, by …
prohormone angiotensinogen by renin and angiotensin I converting enzyme. Angiotensin II, by …
The discovery of potent nonpeptide angiotensin II receptor antagonists: a new class of potent antihypertensives
…, JC Calabrese, PB Timmermans - Journal of medicinal …, 1990 - ACS Publications
A new class of potent antihypertensives has been discovered that exert their effect through
blockade of the angiotensin II (All) receptor. Most AH antagonists reported so far are peptide …
blockade of the angiotensin II (All) receptor. Most AH antagonists reported so far are peptide …
Identification of Nuclear Export Inhibitors with Potent Anticancer Activity In vivo
…, SD Dong, SL Ward, DA Craig, PB Timmermans… - Cancer research, 2009 - AACR
The export protein CRM1 is required for the nuclear export of a wide variety of cancer-related
“cargo” proteins including p53, c-Abl, and FOXO-3A. Leptomycin B (LMB) is a highly …
“cargo” proteins including p53, c-Abl, and FOXO-3A. Leptomycin B (LMB) is a highly …
Nonpeptide angiotensin II receptor antagonists. XI. Pharmacology of EXP3174: an active metabolite of DuP 753, an orally active antihypertensive agent.
…, RR Wexler, AL Johnson, PB Timmermans - … of Pharmacology and …, 1990 - ASPET
This report describes the pharmacology of (2-n-butyl-4-chloro-1- [(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]imidazole-5-carboxylic
acid (EXP3174). EXP3174 is a major metabolite …
acid (EXP3174). EXP3174 is a major metabolite …
The discovery of DuP 753, a potent, orally active nonpeptide angiotensin II receptor antagonist
…, PC Wong, RR Wexler, PB Timmermans - Medicinal research …, 1992 - Wiley Online Library
One of the most important regulators of blood pressure is the renin-angiotensin system (RAS)(Fig.
l).* The enzyme renin, manufactured in the kidney, cleaves circulating …
l).* The enzyme renin, manufactured in the kidney, cleaves circulating …
Selective, covalent modification of β-tubulin residue Cys-239 by T138067, an antitumor agent with in vivo efficacy against multidrug-resistant tumors
…, JC Jaen, T Rosen, PB Timmermans… - Proceedings of the …, 1999 - National Acad Sciences
Microtubules are linear polymers of α- and β-tubulin heterodimers and are the major
constituents of mitotic spindles, which are essential for the separation of chromosomes during …
constituents of mitotic spindles, which are essential for the separation of chromosomes during …