Diffraction (X-ray, neutron and electron) and electron cryo-microscopy are powerful
methods to determine three-dimensional macromolecular structures, which are required to …

Cellular senescence is a cell state implicated in various physiological processes and a wide
spectrum of age-related diseases. Recently, interest in therapeutically targeting senescence …

X-ray crystallography is a critical tool in the study of biological systems. It is able to provide
information that has been a prerequisite to understanding the fundamentals of life. It is also a …

… The ADAMs contain prodomain and metalloprotease domains; the fold of the … with
experimental data that suggest that the ADAM prodomain inhibits metalloprotease activity using a …

Macromolecular X-ray crystallography is routinely applied to understand biological processes
at a molecular level. However, significant time and effort are still required to solve and …

… j, U local,i and U local,j are the corresponding isotropic ADPs and p and q are empirical
constants. By default, R, p and q are fixed at empirically derived values of 5.0 Å, 1.69 and 1.03, …

A new software suite, called Crystallography & NMR System (CNS), has been developed for
macromolecular structure determination by X-ray crystallography or solution nuclear …

Risk for late-onset Alzheimer’s disease (LOAD), the most prevalent dementia, is partially
driven by genetics. To identify LOAD risk loci, we performed a large genome-wide association …

Macroautophagy (hereafter referred to as autophagy) is a catabolic membrane trafficking
process that degrades a variety of cellular constituents and is associated with human diseases …

… used here does not refer to the degeneracy in the coordinates of the first MR model to be
fixed in space groups with an undefined origin (eg the y coordinate in the standard setting of P2 …