Distinct effects of individual opioids on the morphology of spines depend upon the internalization of mu opioid receptors

D Liao, OO Grigoriants, W Wang, K Wiens… - Molecular and Cellular …, 2007 - Elsevier
This study has examined the relationship between the effects of opioids on the internalization
of mu opioid receptors (MORs) and the morphology of dendritic spines. Several opioids (…

Agonist-dependent postsynaptic effects of opioids on miniature excitatory postsynaptic currents in cultured hippocampal neurons

D Liao, OO Grigoriants, HH Loh… - Journal of …, 2007 - journals.physiology.org
Although chronic treatment with morphine is known to alter the function and morphology of
excitatory synapses, the effects of other opioids on these synapses are not clear. Here we …

Stereochemistry as a determinant of the anti-leukemic potency of halopyridyl and thiazolyl thiourea compounds

…, A Benyunov, OO Grigoriants… - Letters in Drug …, 2007 - ingentaconnect.com
Chiral derivatives of two cyclohexylethyl halopyridyl thiourea compounds (HI-509 and HI-510),
two α -methyl benzyl halopyridyl compounds (HI-511 and HI-512), and a cyclohexyl ethyl …

In vivo disposition of dermorphin analog (DALDA) in nonpregnant and pregnant sheep

…, DM Desiderio, PW Schiller, OO Grigoriants… - … of Pharmacology and …, 1998 - ASPET
Although synthetic opioid peptide analogs have been used extensively to study the functional
roles of opioid receptors, little is known about their in vivo disposition. Our goal was to …

Mass spectrometric quantification of the mu opioid receptor agonist Tyr-D-Arg-Phe-Lys-NH2 (DALDA) in high-performance liquid chromatography-purified ovine …

OO Grigoriants, JL Tseng, RR Becklin… - … of Chromatography B …, 1997 - Elsevier
The mu opioid receptor agonist Tyr-d-Arg-Phe-Lys-Amide (d-Arg 2 -Lys 4 -Dermorphin 1-4
amide=DALDA) was infused continuously for 2 h into sheep. The presence of DALDA in ovine …

Alteration of opioid peptide concentrations in the rat pituitary following survivable closed head injury

OO Grigoriants, SV Pravdenkova, BJ Andersen… - Neurochemical …, 1995 - Springer
Concentration changes of methionine enkephalin-like immjnoreactivity (ME-li) and β-endorphin-like
immunoreactivity (BE-li) in the rat pituitary following diffuse brain injury were studied. …

β‐Endorphin1–31 in the rat pituitary Discrepancy between the molecular masses of the DNA‐deduced peptide and of the mass spectrometric‐measured endogenous …

OO GRIGORIANTS… - International Journal of …, 1996 - Wiley Online Library
Mass spectrometry was used to determine the molecular mass of rat pituitary β‐endorphin 1–31
(BE rat, 1–31 The measured molecular mass (3435 ± 1 Da, n= 5) of endogenous BE rat, …

Anti-Proliferative and Anti-Leukemic Activity of DDE46 (Compound WHI-07), a Novel Bromomethoxylated Arylphos-phate Derivative of Zidovudine, and Related …

…, TK Venkatachalam, OO Grigoriants… - …, 2005 - thieme-connect.com
The anti-proliferative effects of a novel bromomethoxylated arylphosphate derivative of
zidovudine (compound DDE46, CAS 213982-96-8) were first examined in a zebra fish embryo …

Dopamine antagonist haloperidol increases carboxypeptidase E mRNA in rat neurointermediate pituitary but not in various other rat tissues

O Grigoriants, L Devi, LD Fricker - Molecular brain research, 1993 - Elsevier
Carboxypeptidase E (CPE) is involved with the biosynthesis of many neuropeptides, including
several whose genes are regulated by haloperidol treatments. In this study, we examined …

[HTML][HTML] Stomatological problems and infectious complications after hematopoietic stem cell transplantation

AP Grigoriants, IM Rabinowitch… - Cellular Therapy and …, 2017 - cyberleninka.ru
The review article deals with early and late oral and dental problems occurring after
intensive anticancer chemoand radiotherapy and hematopoietic stem cell transplantation (HSCT). …