The role of glycogen synthase kinase-3 in insulin resistance and type 2 diabetes

H Eldar-Finkelman, O Kaidanovich - Expert opinion on therapeutic …, 2002 - Taylor & Francis
Glycogen synthase kinase-3 (GSK-3) is a ubiquitous cytosolic serine/threonine protein kinase
that has been implicated in multiple receptor-mediated intracellular processes. Its unique …

Inhibition of glycogen synthase kinase-3β by bivalent zinc ions: insight into the insulin-mimetic action of zinc

R Ilouz, O Kaidanovich, D Gurwitz… - … and biophysical research …, 2002 - Elsevier
Zinc is an important trace element found in most body tissues as bivalent cations and has
essential roles in human health. The insulin-like effect of zinc cations raises the possibility that …

Insulin mimetic action of synthetic phosphorylated peptide inhibitors of glycogen synthase kinase-3

B Plotkin, O Kaidanovich, I Talior… - Journal of Pharmacology …, 2003 - ASPET
Glycogen synthase kinase-3 (GSK-3) was shown to be a key factor in attenuation of the
cellular action of insulin. We speculated that inhibition of GSK-3 might have a potential …

[HTML][HTML] GSK-3: functional insights from cell biology and animal models

O Kaidanovich-Beilin, JR Woodgett - Frontiers in molecular …, 2011 - frontiersin.org
Glycogen synthase kinase-3 (GSK-3) is a widely expressed and highly conserved serine/threonine
protein kinase encoded in mammals by two genes that generate two related proteins: …

Alzheimer's disease in humans and other animals: a consequence of postreproductive life span and longevity rather than aging

D Gunn-Moore, O Kaidanovich-Beilin, MCG Iradi… - Alzheimer's & …, 2018 - Elsevier
Introduction Alzheimer's disease and diabetes mellitus are linked by epidemiology, genetics,
and molecular pathogenesis. They may also be linked by the remarkable observation that …

Assessment of social interaction behaviors

O Kaidanovich-Beilin, T Lipina, I Vukobradovic… - JoVE (Journal of …, 2011 - jove.com
Social interactions are a fundamental and adaptive component of the biology of numerous
species. Social recognition is critical for the structure and stability of the networks and …

Rapid antidepressive-like activity of specific glycogen synthase kinase-3 inhibitor and its effect on β-catenin in mouse hippocampus

O Kaidanovich-Beilin, A Milman, A Weizman… - Biological …, 2004 - Elsevier
BACKGROUND: Inhibition of glycogen synthase kinase-3 (GSK-3) is thought to be a key
feature in the therapeutic mechanism of several mood stabilizers; however, the role of GSK-3 in …

[HTML][HTML] Abnormalities in brain structure and behavior in GSK-3alpha mutant mice

O Kaidanovich-Beilin, TV Lipina, K Takao, M Van Eede… - Molecular brain, 2009 - Springer
Background Glycogen synthase kinase-3 (GSK-3) is a widely expressed and highly conserved
serine/threonine protein kinase encoded by two genes that generate two related proteins: …

Risk of cardiovascular events and death associated with initiation of SGLT2 inhibitors compared with DPP-4 inhibitors: an analysis from the CVD-REAL 2 multinational …

…, M Greenbloom, O Kaidanovich-Beilin… - The Lancet Diabetes & …, 2020 - thelancet.com
Background Cardiovascular outcome trials have shown cardiovascular benefit with sodium-glucose
co-transporter-2 (SGLT2) inhibitors in patients with type 2 diabetes, whereas …

Genetic and pharmacological evidence for schizophrenia‐related disc1 interaction with GSK‐3

TV Lipina, O Kaidanovich‐Beilin, S Patel, M Wang… - Synapse, 2011 - Wiley Online Library
Recent studies have identified disrupted‐in‐schizophrenia‐1 (DISC1) as a strong genetic
risk factor associated with schizophrenia. Previously, we have reported that a mutation in the …