Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides
Cardiovascular disease remains the leading cause of mortality in westernized countries,
despite optimum medical therapy to reduce the levels of low-density lipoprotein (LDL)-…
despite optimum medical therapy to reduce the levels of low-density lipoprotein (LDL)-…
Nitric oxide is a mediator of the decrease in cytochrome P450-dependent metabolism caused by immunostimulants.
OG Khatsenko, SS Gross… - Proceedings of the …, 1993 - National Acad Sciences
… 7-ethoxyresorufin O-deethylation and benzyloxyresorufin O-dealkylation are
complementary to our findings. We also found inhibition of 7-ethoxyresorufin as well as 7-PR-O-dealkylase …
complementary to our findings. We also found inhibition of 7-ethoxyresorufin as well as 7-PR-O-dealkylase …
Discovery of CC-930, an orally active anti-fibrotic JNK inhibitor
…, B Bennett, M Moghaddam, O Khatsenko… - Bioorganic & medicinal …, 2012 - Elsevier
In this Letter we describe the discovery of potent, selective, and orally active aminopurine
JNK inhibitors. Improving the physico-chemical properties as well as increasing the potency …
JNK inhibitors. Improving the physico-chemical properties as well as increasing the potency …
Absolute bioavailability of 2′-O-(2-methoxyethyl)-modified antisense oligonucleotides following intraduodenal instillation in rats
RS Geary, O Khatsenko, K Bunker, R Crooke… - … of Pharmacology and …, 2001 - ASPET
Three modified 20-mer antisense oligonucleotides targeted to human intercellular adhesion
molecule-1 mRNA were characterized for their presystemic stability and oral bioavailability …
molecule-1 mRNA were characterized for their presystemic stability and oral bioavailability …
Nitric oxide differentially affects constitutive cytochrome P450 isoforms in rat liver
O Khatsenko, Y Kikkawa - Journal of Pharmacology and Experimental …, 1997 - ASPET
Recently nitric oxide (NO) was suggested as a final mediator of down-regulation of cytochrome
P450 by bacterial lipopolysaccaride (LPS). One proposed mechanism is based on the …
P450 by bacterial lipopolysaccaride (LPS). One proposed mechanism is based on the …
Aminopurine based JNK inhibitors for the prevention of ischemia reperfusion injury
…, M Celeridad, M Moghaddam, O Khatsenko… - Bioorganic & medicinal …, 2012 - Elsevier
In this Letter we describe the optimization of an aminopurine lead (1) with modest potency
and poor overall kinase selectivity which led to the identification of a series of potent, selective …
and poor overall kinase selectivity which led to the identification of a series of potent, selective …
Absorption of antisense oligonucleotides in rat intestine: effect of chemistry and length
O KHATSENKO, R MORGAN, L TRUONG… - … and Nucleic Acid …, 2000 - liebertpub.com
An in situ single-pass perfusion model was used to assess the effect of chemical modification
and length on permeability and absorption of various oligonucleotides in rat intestine. …
and length on permeability and absorption of various oligonucleotides in rat intestine. …
[HTML][HTML] Interactions between nitric oxide and cytochrome P-450 in the liver
O Khatsenko - BIOCHEMISTRY C/C OF BIOKHIMIIA, 1998 - protein.bio.msu.ru
Bacterial lipopolysaccharide and a diverse array of other immunostimulants and cytokines
suppress the metabolism of endogenous and exogenous substances by reducing the activity …
suppress the metabolism of endogenous and exogenous substances by reducing the activity …
Evidence for nitric oxide participation in down-regulation of CYP2B1/2 gene expression at the pretranslational level
OG Khatsenko, AR Boobis, SS Gross - Toxicology letters, 1997 - Elsevier
Septic or inflammatory stimuli suppress drug metabolism by cytochrome P-450 in the liver,
presumably at the pretranslational level. We have shown previously that nitric oxide is …
presumably at the pretranslational level. We have shown previously that nitric oxide is …
Role of nitric oxide in the inhibition of cytochrome P450 in the liver of mice infected with Chlamydia trachomatis
OG Khatsenko, NS Barteneva, LM de la Maza… - Biochemical …, 1998 - Elsevier
In this study, we attempted to determine the effect of a systemic infection with Chlamydia
trachomatis on cytochrome P450(CYP)-dependent metabolism in mice. Furthermore, we …
trachomatis on cytochrome P450(CYP)-dependent metabolism in mice. Furthermore, we …