Clinical differences between interstitial lung disease associated with clinically amyopathic dermatomyositis and classic dermatomyositis
H Mukae, H Ishimoto, N Sakamoto, S Hara… - Chest, 2009 - Elsevier
Background Interstitial lung disease (ILD) associated with clinically amyopathic
dermatomyositis (CADM) is a potentially fatal condition in which the clinical features are not well …
dermatomyositis (CADM) is a potentially fatal condition in which the clinical features are not well …
Pirfenidone inhibits the expression of HSP47 in TGF-β1-stimulated human lung fibroblasts
S Nakayama, H Mukae, N Sakamoto, T Kakugawa… - Life sciences, 2008 - Elsevier
Pirfenidone (5-methyl-1-phenyl-2-(1H)-pyridone) is a novel anti-fibrotic and anti-inflammatory
agent that inhibits the progression of fibrosis in animal models and patients with idiopathic …
agent that inhibits the progression of fibrosis in animal models and patients with idiopathic …
Differences in response to pulmonary rehabilitation in idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease
R Kozu, H Senjyu, SC Jenkins, H Mukae, N Sakamoto… - Respiration, 2011 - karger.com
Background: The benefits of pulmonary rehabilitation in chronic obstructive pulmonary
disease (COPD) are well recognized. However, whether individuals with idiopathic pulmonary …
disease (COPD) are well recognized. However, whether individuals with idiopathic pulmonary …
[HTML][HTML] Pirfenidone inhibits TGF-β1-induced over-expression of collagen type I and heat shock protein 47 in A549 cells
K Hisatomi, H Mukae, N Sakamoto, Y Ishimatsu… - BMC Pulmonary …, 2012 - Springer
Background Pirfenidone is a novel anti-fibrotic and anti-inflammatory agent that inhibits the
progression of fibrosis in animal models and in patients with idiopathic pulmonary fibrosis (…
progression of fibrosis in animal models and in patients with idiopathic pulmonary fibrosis (…
[HTML][HTML] Alveolar macrophage-epithelial cell interaction following exposure to atmospheric particles induces the release of mediators involved in monocyte …
…, S Hayashi, JC Hogg, T Fujii, Y Goto, N Sakamoto… - Respiratory …, 2005 - Springer
Background Studies from our laboratory have shown that human alveolar macrophages (AM)
and bronchial epithelial cells (HBEC) exposed to ambient particles (PM 10 ) in vitro …
and bronchial epithelial cells (HBEC) exposed to ambient particles (PM 10 ) in vitro …
[HTML][HTML] Hsp47: A therapeutic target in pulmonary fibrosis
N Sakamoto, D Okuno, T Tokito, H Yura, T Kido… - Biomedicines, 2023 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease characterized by a progressive
decline in lung function and poor prognosis. The deposition of the extracellular matrix (ECM) …
decline in lung function and poor prognosis. The deposition of the extracellular matrix (ECM) …
[HTML][HTML] S100A9 in BALF is a candidate biomarker of idiopathic pulmonary fibrosis
A Hara, N Sakamoto, Y Ishimatsu, T Kakugawa… - Respiratory …, 2012 - Elsevier
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a specific form of chronic, progressive
fibrosing interstitial pneumonia of unknown cause, and the prognosis remains poor. On the …
fibrosing interstitial pneumonia of unknown cause, and the prognosis remains poor. On the …
Differential effects of α-and β-defensin on cytokine production by cultured human bronchial epithelial cells
N Sakamoto, H Mukae, T Fujii, H Ishii… - … of Physiology-Lung …, 2005 - journals.physiology.org
Defensins are cysteine-rich cationic antimicrobial peptides that play an important role in
innate immunity and are known to contribute to the regulation of host adaptive immunity. In …
innate immunity and are known to contribute to the regulation of host adaptive immunity. In …
Serum interferon-α is a useful biomarker in patients with anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive dermatomyositis
…, H Ida, T Kakugawa, N Sakamoto… - Modern …, 2015 - academic.oup.com
Objective. We have tried to clarify the clinical importance of the measurement of serum type-I
interferon (IFN) in patients with anti-melanoma differentiation-associated gene 5 Ab (MDA5 …
interferon (IFN) in patients with anti-melanoma differentiation-associated gene 5 Ab (MDA5 …
A fatal case of acute exacerbation of interstitial lung disease in a patient with rheumatoid arthritis during treatment with tocilizumab
S Kawashiri, A Kawakami, N Sakamoto… - Rheumatology …, 2012 - Springer
A 68-year-old man, who was a patient with established rheumatoid arthritis (RA) with RA-associated
interstitial lung disease (RA-ILD) and pulmonary emphysema, began taking …
interstitial lung disease (RA-ILD) and pulmonary emphysema, began taking …