TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand

…, T Hori, GJ Delespesse, N Watanabe… - The Journal of …, 2005 - rupress.org
We recently showed that dendritic cells (DCs) activated by thymic stromal lymphopoietin (TSLP)
prime naive CD4 + T cells to differentiate into T helper type 2 (Th2) cells that produced …

Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus

N Watanabe, YH Wang, HK Lee, T Ito, YH Wang… - Nature, 2005 - nature.com
Hassall's corpuscles—first described in the human thymus over 150 years ago 1 —are groups
of epithelial cells within the thymic medulla. The physical nature of these structures differs …

BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1

N Watanabe, M Gavrieli, JR Sedy, J Yang… - Nature …, 2003 - nature.com
During activation, T cells express receptors for receiving positive and negative costimulatory
signals. Here we identify the B and T lymphocyte attenuator (BTLA), an immunoglobulin …

TSLP: an epithelial cell cytokine that regulates T cell differentiation by conditioning dendritic cell maturation

YJ Liu, V Soumelis, N Watanabe, T Ito… - Annu. Rev …, 2007 - annualreviews.org
Dendritic cells (DCs) are professional antigen-presenting cells that have the ability to sense
infection and tissue stress, sample and present antigen to T lymphocytes, and induce …

IL-23 and Th17 cells enhance Th2-cell–mediated eosinophilic airway inflammation in mice

…, S Kagami, A Suto, N Watanabe… - American journal of …, 2008 - atsjournals.org
Rationale: The IL-23–IL-17A–producing CD4 + T-cell (Th17 cell) axis plays an important
role in the development of chronic inflammatory diseases, including autoimmune diseases. …

[HTML][HTML] Maintenance and polarization of human TH2 central memory T cells by thymic stromal lymphopoietin-activated dendritic cells

YH Wang, T Ito, YH Wang, B Homey, N Watanabe… - Immunity, 2006 - cell.com
The identity of T H 2 memory cells and the mechanism regulating their maintenance during
allergic inflammation remain elusive. We report that circulated human CD4 + T cells …

Human thymic stromal lymphopoietin promotes dendritic cell–mediated CD4+ T cell homeostatic expansion

N Watanabe, S Hanabuchi, V Soumelis, W Yuan… - Nature …, 2004 - nature.com
T cell homeostasis is a self-regulating process for maintaining the size of the peripheral T
cell pool. Although dendritic cells (DCs) seem to be important in T cell homeostasis, the …

Long-term clinical outcome of gastric MALT lymphoma after eradication of Helicobacter pylori: a multicentre cohort follow-up study of 420 patients in Japan

…, H Matsumoto, T Nagaya, T Kamoshida, N Watanabe… - Gut, 2012 - gut.bmj.com
Objective A multicentre cohort follow-up study of a large number of patients with gastric
mucosa-associated lymphoid tissue (MALT) lymphoma was conducted to elucidate the long-term …

Development and characterization of IL-21–producing CD4+ T cells

…, S Kagami, K Hirose, N Watanabe… - The Journal of …, 2008 - rupress.org
It has recently been shown that interleukin (IL)-21 is produced by Th17 cells, functions as an
autocrine growth factor for Th17 cells, and plays critical roles in autoimmune diseases. In …

IL-25 enhances allergic airway inflammation by amplifying a TH2 cell–dependent pathway in mice

…, Y Seto, A Suto, K Suzuki, N Watanabe… - Journal of allergy and …, 2006 - Elsevier
BACKGROUND: A novel IL-17 family cytokine, IL-25, has been reported to induce IL-4, IL-5,
and IL-13 production from undefined non-T/non-B cells and then induce T H 2-type immune …