There is accumulating evidence that most β-lactam antibiotics (ie, cephalosporins and
penicillins) have some degree of convulsive activity, both in laboratory animals as well as in …

Fibromyalgia is a prevalent and burdensome disorder characterized by chronic widespread
pain and complex comorbid symptoms. To develop better treatments for pain-centered …

γ-Secretase inhibitors (GSIs) reduce amyloid-β (Aβ) peptides but inevitably increase the β-C-terminal
fragment (β-CTF) of amyloid precursor protein (APP), potentially having …

Nerve growth factor (NGF) and other members of the neurotrophin family are critical for the
survival and differentiation of neurons and have been implicated in the pathophysiology of …

Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear receptor
superfamily and function as ligand-modulated transcription factors that regulate gene …

Aloe has been used as a folk medicine because it has several important therapeutic
properties. These include wound and burn healing, and Aloe is now used in a variety of …

Central adenosine A 2A receptor is a promising target for drugs to treat Parkinson's disease
(PD), and the central blockade of adenosine A 1 receptor improves cognitive function. In the …

We disclose herein our efforts aimed at discovery of selective PARP-1 and PARP-2 inhibitors.
We have recently discovered several novel classes of quinazolinones, quinazolidinones, …

A novel class of quinazolinone derivatives as potent poly(ADP-ribose)polymerase-1 (PARP-1)
inhibitors has been discovered. Key to success was application of a rational discovery …

Two classes of quinazolinone derivatives and quinoxaline derivatives were identified as
potent and selective poly(ADP-ribose) polymerase-1 and 2 (PARP-1) and (PARP-2) inhibitors, …