User profiles for Nikolai B. Fedorov
Nikolai FedorovPrincipal Scientist, Charles River Laboratories Verified email at crl.com Cited by 3605 |
Autophosphorylation at Thr286 of the α Calcium-Calmodulin Kinase II in LTP and Learning
The calcium-calmodulin–dependent kinase II (CaMKII) is required for hippocampal long-term
potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)–…
potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)–…
[PDF][PDF] Inhibitory autophosphorylation of CaMKII controls PSD association, plasticity, and learning
Y Elgersma, NB Fedorov, S Ikonen, ES Choi… - Neuron, 2002 - cell.com
To investigate the function of the α calcium-calmodulin-dependent kinase II (αCaMKII)
inhibitory autophosphorylation at threonines 305 and/or 306, we generated knockin mice that …
inhibitory autophosphorylation at threonines 305 and/or 306, we generated knockin mice that …
Reduced K+ channel inactivation, spike broadening, and after-hyperpolarization in Kvβ1. 1-deficient mice with impaired learning
A-type K + channels are known to regulate neuronal firing, but their role in repetitive firing
and learning in mammals is not well characterized. To determine the contribution of the …
and learning in mammals is not well characterized. To determine the contribution of the …
Hippocampus-dependent learning and memory is impaired in mice lacking the Ras-guanine-nucleotide releasing factor 1 (Ras-GRF1)
KP Giese, E Friedman, JB Telliez, NB Fedorov… - …, 2001 - Elsevier
Previous results have suggested that the Ras signaling pathway is involved in learning and
memory. Ras is activated by nucleotide exchange factors, such as the calmodulin-activated …
memory. Ras is activated by nucleotide exchange factors, such as the calmodulin-activated …
Structural differences determine the relative selectivity of nicotinic compounds for native α4β2*-, α6β2*-, α3β4*-and α7-nicotine acetylcholine receptors
…, D Yohannes, CR Wageman, NB Fedorov… - …, 2010 - Elsevier
Mammalian brain expresses multiple nicotinic acetylcholine receptor (nAChR) subtypes that
differ in subunit composition, sites of expression and pharmacological and functional …
differ in subunit composition, sites of expression and pharmacological and functional …
[HTML][HTML] Increased neuronal excitability, synaptic plasticity, and learning in aged Kvβ1. 1 knockout mice
Background: Advancing age is typically accompanied by deficits in learning and memory.
These deficits occur independently of overt pathology and are often considered to be a part of "…
These deficits occur independently of overt pathology and are often considered to be a part of "…
Molecular, cellular, and neuroanatomical substrates of place learning
Learning and remembering the location of food resources, predators, escape routes, and
immediate kin is perhaps the most essential form of higher cognitive processing in mammals. …
immediate kin is perhaps the most essential form of higher cognitive processing in mammals. …
Discovery of (2S,3R)-N-[2-(Pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]oct-3-yl]benzo[b]furan-2-carboxamide (TC-5619), a Selective α7 Nicotinic Acetylcholine Receptor …
…, L Miao, G Dull, JF Genus, NB Fedorov… - Journal of medicinal …, 2012 - ACS Publications
(2S,3R)-N-[2-(Pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]oct-3-yl]benzo[b]furan-2-carboxamide (7a,
TC-5619), a novel selective agonist of the α7 neuronal nicotinic acetylcholine receptor, …
TC-5619), a novel selective agonist of the α7 neuronal nicotinic acetylcholine receptor, …
Personalized medicine: Vinpocetine to reverse effects of GABRB3 mutation
…, JM Andresen, BC Gay, GR Stewart, NB Fedorov… - …, 2019 - Wiley Online Library
Objective To screen a library of potential therapeutic compounds for a woman with Lennox‐Gastaut
syndrome due to a Y302C GABRB3 (c.905A>G) mutation. Methods We compared …
syndrome due to a Y302C GABRB3 (c.905A>G) mutation. Methods We compared …
Differential pharmacologies of mecamylamine enantiomers: positive allosteric modulation and noncompetitive inhibition
NB Fedorov, LC Benson, J Graef, PM Lippiello… - … of Pharmacology and …, 2009 - ASPET
(±)-Mecamylamine is a racemic mixture of a widely used brain-permeant noncompetitive
inhibitor of muscle-type and neuronal nicotinic receptors (NNRs). The present studies …
inhibitor of muscle-type and neuronal nicotinic receptors (NNRs). The present studies …