User profiles for Nikolai B. Fedorov

Nikolai Fedorov

Principal Scientist, Charles River Laboratories
Verified email at crl.com
Cited by 3605

Autophosphorylation at Thr286 of the α Calcium-Calmodulin Kinase II in LTP and Learning

KP Giese, NB Fedorov, RK Filipkowski, AJ Silva - Science, 1998 - science.org
The calcium-calmodulin–dependent kinase II (CaMKII) is required for hippocampal long-term
potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)–…

[PDF][PDF] Inhibitory autophosphorylation of CaMKII controls PSD association, plasticity, and learning

Y Elgersma, NB Fedorov, S Ikonen, ES Choi… - Neuron, 2002 - cell.com
To investigate the function of the α calcium-calmodulin-dependent kinase II (αCaMKII)
inhibitory autophosphorylation at threonines 305 and/or 306, we generated knockin mice that …

Reduced K+ channel inactivation, spike broadening, and after-hyperpolarization in Kvβ1. 1-deficient mice with impaired learning

KP Giese, JF Storm, D Reuter, NB Fedorov… - Learning & …, 1998 - learnmem.cshlp.org
A-type K + channels are known to regulate neuronal firing, but their role in repetitive firing
and learning in mammals is not well characterized. To determine the contribution of the …

Hippocampus-dependent learning and memory is impaired in mice lacking the Ras-guanine-nucleotide releasing factor 1 (Ras-GRF1)

KP Giese, E Friedman, JB Telliez, NB Fedorov… - …, 2001 - Elsevier
Previous results have suggested that the Ras signaling pathway is involved in learning and
memory. Ras is activated by nucleotide exchange factors, such as the calmodulin-activated …

Structural differences determine the relative selectivity of nicotinic compounds for native α4β2*-, α6β2*-, α3β4*-and α7-nicotine acetylcholine receptors

…, D Yohannes, CR Wageman, NB Fedorov… - …, 2010 - Elsevier
Mammalian brain expresses multiple nicotinic acetylcholine receptor (nAChR) subtypes that
differ in subunit composition, sites of expression and pharmacological and functional …

[HTML][HTML] Increased neuronal excitability, synaptic plasticity, and learning in aged Kvβ1. 1 knockout mice

GG Murphy, NB Fedorov, KP Giese, M Ohno… - Current Biology, 2004 - cell.com
Background: Advancing age is typically accompanied by deficits in learning and memory.
These deficits occur independently of overt pathology and are often considered to be a part of "…

Molecular, cellular, and neuroanatomical substrates of place learning

AJ Silva, KP Giese, NB Fedorov, PW Frankland… - Neurobiology of learning …, 1998 - Elsevier
Learning and remembering the location of food resources, predators, escape routes, and
immediate kin is perhaps the most essential form of higher cognitive processing in mammals. …

Discovery of (2S,3R)-N-[2-(Pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]oct-3-yl]benzo[b]furan-2-carboxamide (TC-5619), a Selective α7 Nicotinic Acetylcholine Receptor …

…, L Miao, G Dull, JF Genus, NB Fedorov… - Journal of medicinal …, 2012 - ACS Publications
(2S,3R)-N-[2-(Pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]oct-3-yl]benzo[b]furan-2-carboxamide (7a,
TC-5619), a novel selective agonist of the α7 neuronal nicotinic acetylcholine receptor, …

Personalized medicine: Vinpocetine to reverse effects of GABRB3 mutation

…, JM Andresen, BC Gay, GR Stewart, NB Fedorov… - …, 2019 - Wiley Online Library
Objective To screen a library of potential therapeutic compounds for a woman with Lennox‐Gastaut
syndrome due to a Y302C GABRB3 (c.905A>G) mutation. Methods We compared …

Differential pharmacologies of mecamylamine enantiomers: positive allosteric modulation and noncompetitive inhibition

NB Fedorov, LC Benson, J Graef, PM Lippiello… - … of Pharmacology and …, 2009 - ASPET
(±)-Mecamylamine is a racemic mixture of a widely used brain-permeant noncompetitive
inhibitor of muscle-type and neuronal nicotinic receptors (NNRs). The present studies …