Trace amines: identification of a family of mammalian G protein-coupled receptors
B Borowsky, N Adham, KA Jones… - Proceedings of the …, 2001 - National Acad Sciences
Tyramine, β-phenylethylamine, tryptamine, and octopamine are biogenic amines present in
trace levels in mammalian nervous systems. Although some “trace amines” have clearly …
trace levels in mammalian nervous systems. Although some “trace amines” have clearly …
[HTML][HTML] Cloning of a novel human serotonin receptor (5-HT7) positively linked to adenylate cyclase.
JA Bard, J Zgombick, N Adham, P Vaysse… - Journal of Biological …, 1993 - Elsevier
An intron-containing gene encoding a novel human serotonin (5-HT) receptor was isolated
from human genomic and cDNA libraries with probes directed to transmembrane regions of …
from human genomic and cDNA libraries with probes directed to transmembrane regions of …
[HTML][HTML] Identification and characterization of two G protein-coupled receptors for neuropeptide FF
JA Bonini, KA Jones, N Adham, C Forray… - Journal of Biological …, 2000 - ASBMB
The central nervous system octapeptide, neuropeptide FF (NPFF), is believed to play a role
in pain modulation and opiate tolerance. Two G protein-coupled receptors, NPFF1 and …
in pain modulation and opiate tolerance. Two G protein-coupled receptors, NPFF1 and …
Cariprazine (RGH-188), a dopamine D3 receptor-preferring, D3/D2 dopamine receptor antagonist–partial agonist antipsychotic candidate: in vitro and neurochemical …
…, G Domány, K Tihanyi, N Adham… - … of Pharmacology and …, 2010 - ASPET
Cariprazine {RGH-188; trans-N-[4-[2-[4-(2,3-dichlorophenyl)piperazin-1-yl]ethyl]cyclohexyl]-N′,N′-dimethylurea
hydrochloride}, a novel candidate antipsychotic, demonstrated …
hydrochloride}, a novel candidate antipsychotic, demonstrated …
Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase.
N Adham, HT Kao, LE Schecter… - Proceedings of the …, 1993 - National Acad Sciences
An intronless gene encoding an additional human serotonin (5-HT) 5-HT1-like receptor subtype
was isolated from a human genomic library with probes obtained from degenerate PCR …
was isolated from a human genomic library with probes obtained from degenerate PCR …
[HTML][HTML] Identification and characterization of two neuromedin U receptors differentially expressed in peripheral tissues and the central nervous system
…, TA Branchek, C Gerald, C Forray, N Adham - Journal of Biological …, 2000 - ASBMB
Two structurally related, G-protein-coupled receptors were identified as receptors for the
neuropeptide, neuromedin U. This peptide is found in highest levels in the gut and genitourinary …
neuropeptide, neuromedin U. This peptide is found in highest levels in the gut and genitourinary …
5-HT1F receptor agonists inhibit neurogenic dural inflammation in guinea pigs
…, JE Audia, SW Kaldor, ME Flaugh, N Adham… - …, 1997 - journals.lww.com
THE serotonin (5-HT) receptor subtype mediating inhibition of neurogenic dural inflammation
in guinea pigs was investigated using a series of serotonin agonists with differing affinities …
in guinea pigs was investigated using a series of serotonin agonists with differing affinities …
[PDF][PDF] The rat 5-hydroxytryptamine1B receptor is the species homologue of the human 5-hydroxytryptamine1D beta receptor.
N Adham, P Romanienko, P Hartig… - Molecular …, 1992 - Citeseer
The relationship between the serotonin 5-hydroxytryptaminelB (5-HT1B) and 5-HT1D
receptors has been the topic of much investigation and speculation since their complementary …
receptors has been the topic of much investigation and speculation since their complementary …
[HTML][HTML] Preferential binding to dopamine D3 over D2 receptors by cariprazine in patients with schizophrenia using PET with the D3/D2 receptor ligand [11C]-(+) …
…, P Ghahramani, I Laszlovszky, S Durgam, N Adham… - …, 2016 - Springer
Rationale Second-generation antipsychotics occupy dopamine D 2 receptors and act as
antagonists or partial agonists at these receptors. While these drugs alleviate positive …
antagonists or partial agonists at these receptors. While these drugs alleviate positive …
Cariprazine, a dopamine D3-receptor-preferring partial agonist, blocks phencyclidine-induced impairments of working memory, attention set-shifting, and recognition …
R Zimnisky, G Chang, I Gyertyán, B Kiss, N Adham… - …, 2013 - Springer
Rationale A major challenge in the pharmacological treatment of psychotic disorders is the
effective management of the associated cognitive dysfunctions. Novel concepts emphasize a …
effective management of the associated cognitive dysfunctions. Novel concepts emphasize a …