[HTML][HTML] Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus
N Méthot, K Basler - Cell, 1999 - cell.com
Hedgehog (Hh) proteins play diverse organizing roles in development by regulating gene
expression in responding cells. The Gli homolog Cubitus interruptus (Ci) is involved in …
expression in responding cells. The Gli homolog Cubitus interruptus (Ci) is involved in …
[HTML][HTML] Characterization of transgenic mice with targeted disruption of the catalytic domain of the double-stranded RNA-dependent protein kinase, PKR
N Abraham, DF Stojdl, PI Duncan, N Méthot… - Journal of Biological …, 1999 - ASBMB
The interferon-inducible, double-stranded RNA-dependent protein kinase PKR has been
implicated in anti-viral, anti-tumor, and apoptotic responses. Others have attempted to examine …
implicated in anti-viral, anti-tumor, and apoptotic responses. Others have attempted to examine …
A region rich in aspartic acid, arginine, tyrosine, and glycine (DRYG) mediates eukaryotic initiation factor 4B (eIF4B) self-association and interaction with eIF3
N Méthot, MS Song, N Sonenberg - Molecular and cellular biology, 1996 - Am Soc Microbiol
The binding of mRNA to the ribosome is mediated by eukaryotic initiation factors eukaryotic
initiation factor 4F (eIF4F), eIF4B, eIF4A, and eIF3. eIF4F binds to the mRNA cap structure …
initiation factor 4F (eIF4F), eIF4B, eIF4A, and eIF3. eIF4F binds to the mRNA cap structure …
Suppressor of fused opposes hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus
N Méthot, K Basler - Development, 2000 - journals.biologists.com
Hedgehog controls the expression of key developmental genes through the conversion of
the transcription factor Cubitus interruptus (Ci) into either an activator (Ci[act]) or a repressor (…
the transcription factor Cubitus interruptus (Ci) into either an activator (Ci[act]) or a repressor (…
Inhibitors of the inducible microsomal prostaglandin E2 synthase (mPGES-1) derived from MK-886
…, S Guiral, H Juteau, JA Mancini, N Méthot… - Bioorganic & medicinal …, 2005 - Elsevier
A series of potent and selective inhibitors of the inducible microsomal PGE 2 synthase (mPGES-1)
has been developed based on the indole FLAP inhibitor MK-886. Compounds 23 and …
has been developed based on the indole FLAP inhibitor MK-886. Compounds 23 and …
MF63 [2-(6-chloro-1H-phenanthro [9, 10-d] imidazol-2-yl)-isophthalonitrile], a selective microsomal prostaglandin E synthase-1 inhibitor, relieves pyresis and pain in …
…, M Salem, Y Ducharme, RW Friesen, N Méthot… - … of Pharmacology and …, 2008 - ASPET
Microsomal prostaglandin E synthase-1 (mPGES-1) is a terminal prostaglandin E 2 (PGE 2 )
synthase in the cyclooxygenase pathway. Inhibitors of mPGES-1 may block PGE 2 …
synthase in the cyclooxygenase pathway. Inhibitors of mPGES-1 may block PGE 2 …
Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors
…, J Mancini, E Martins, F Massé, N Méthot… - Bioorganic & medicinal …, 2007 - Elsevier
Phenanthrene imidazole 3 (MF63) has been identified as a novel potent, selective, and orally
active mPGES-1 inhibitor. This new series was developed by lead optimization of a hit from …
active mPGES-1 inhibitor. This new series was developed by lead optimization of a hit from …
An absolute requirement for Cubitus interruptus in Hedgehog signaling
N Méthot, K Basler - Development, 2001 - journals.biologists.com
Hedgehog (Hh) proteins play diverse organizing roles in animal development by regulating
gene expression in responding cells. Several components of the Hh signal transduction …
gene expression in responding cells. Several components of the Hh signal transduction …
The HRIGRXXR region of the DEAD box RNA helicase eukaryotic translation initiation factor 4A is required for RNA binding and ATP hydrolysis
A Pause, N Méthot, N Sonenberg - Molecular and cellular biology, 1993 - Taylor & Francis
eIF-4A is a eukaryotic translation initiation factor that is required for mRNA binding to ribosomes.
It exhibits single-stranded RNA-dependent ATPase activity, and in combination with a …
It exhibits single-stranded RNA-dependent ATPase activity, and in combination with a …
[HTML][HTML] Inhibition of the activation of multiple serine proteases with a cathepsin C inhibitor requires sustained exposure to prevent pro-enzyme processing
N Méthot, J Rubin, D Guay, C Beaulieu, D Ethier… - Journal of Biological …, 2007 - ASBMB
Cathepsin C is a cysteine protease required for the activation of several pro-inflammatory
serine proteases and, as such, is of interest as a therapeutic target. In cathepsin C-deficient …
serine proteases and, as such, is of interest as a therapeutic target. In cathepsin C-deficient …