The proposal that nitric oxide (NO) or its reactant products mediate toxicity in brain remains
controversial in part because of the use of nonselective agents that block NO formation in …

: Heme oxygenase‐1 (HO‐1, HSP32) is an early gene that is responsive to an array of
pathological conditions including, but not limited to, hypoxia and cerebral ischemia. HO‐1 cleaves …

Infarct volume and edema were assessed after transient focal ischemia in mice lacking neuronal
nitric oxide synthase (NOS) gene expression. With use of an 8–0 coated monofilament, …

Heme oxygenase isozymes, HO-1, HO-2 and HO-3, are HSP32 protein cognates, with a
known function of catalyzing the isomer specific oxidation of the heme molecule, including that …

Biliverdin reductase catalyzes the reduction of biliverdin, the product of heme oxygenase (HO)
activity, to bilirubin. The reductase is unique among all enzymes characterized to date in …

In mammals the rate-limiting step in heme catabolism is the heme oxygenase (HO) system.
Two isozymes, HO-1 and HO-2, oxidatively cleave the substrate to form biliverdin, and the …

The heme oxygenase (HO) isozymes catalyze oxidation of the heme molecule to biliverdin
and carbon monoxide (CO) with the release of chelated iron. Presently, we have defined, for …

THE neuroprotective effect of nerve growth factor (NGF) on the pyramidal cells in the
vulnerable CA1-CA2 sectors of the hippocampus was investigated in a rat model of transient …

PURPOSE To evaluate mechanically detachable coil designs capable of controlled and
instantaneous release within an aneurysm or vascular space. METHODS Three mechanically …

This is the first report on increased neuronal levels of biliverdin reductase (BVR) in response
to ischemic brain injury. BVR is an oxidoreductase, and is unique among all enzymes …