The vanilloid receptor TRPV1 has been identified as a molecular target for the treatment of
pain associated with inflammatory diseases and cancer. Hence, TRPV1 antagonists have …

The vanilloid receptor 1 (VR1 or TRPV1) is a membrane-bound, nonselective cation channel
expressed by peripheral sensory neurons. TRPV1 antagonists produce antihyperalgesic …

Vanilloid receptor 1 (TRPV1), a membrane-associated cation channel, is activated by the
pungent vanilloid from chili peppers, capsaicin, and the ultra potent vanilloid from Euphorbia …

The vanilloid receptor TRPV1 is a homotetrameric, non-selective cation channel abundantly
expressed in the nociceptors (c-fibers). TRPV1 is considered as a highly validated pain …

The vanilloid receptor TRPV1 (transient receptor potential vanilloid 1) is a cation channel that
serves as a polymodal detector of pain-producing stimuli such as capsaicin, protons (pH <…

We studied N-(2-aminoethyl)-N-(4-(benzyloxy)-3-methoxybenzyl)thiophene-2-carboxamide
hydrochloride (M8-B), a selective and potent antagonist of the transient receptor potential …

An involvement of the transient receptor potential vanilloid (TRPV) 1 channel in the regulation
of body temperature (T b ) has not been established decisively. To provide decisive …

Local anesthetics (LAs) block the generation and propagation of action potentials by interacting
with specific sites of voltage-gated Na + channels. LAs can also excite sensory neurons …

The capsaicin receptor TRPV1 is an emerging target for the treatment of pain with a unique
expression profile in peripheral nociceptors and the ability to show polymodal activation, …

Agonists of the transient receptor potential vanilloid type 1 (TRPV1), such as capsaicin, cause
pain and a drop in body temperature (hypothermia). Conversely, antagonists of TRPV1 …