THE disease non-insulin-dependent (type 2) diabetes mellitus (NIDDM) is characterized by
abnormally high blood glucose resulting from a relative deficiency of insulin 1 . It affects …

Type 2 or non-insulin-dependent diabetes mellitus (NIDDM) is the most common form of
diabetes worldwide, affecting approximately 4% of the world's adult population. It is …

We carried out a multistage genome-wide association study of type 2 diabetes mellitus in
Japanese individuals, with a total of 1,612 cases and 1,424 controls and 100,000 SNPs. The …

The allele frequencies for a Pro 12 →Ala substitution in peroxisome proliferator–activated
receptor-γ differ among ethnic groups, and its relationship with diabetes and associated …

Background: In Europeans and populations of European origin, several groups have recently
identified novel type 2 diabetes susceptibility genes, including FTO, SLC30A8, HHEX, …

Variation in the calpain-10 gene (CAPN10 [MIM 605286]) was recently linked and associated
with type 2 diabetes mellitus (T2DM) susceptibility (Horikawa et al. 2000). The initial …

Organic cation transporter 1 (OCT1; SLC22A1) seems to play a role in the efficacy and
disposition of the widely used antidiabetic drug metformin. Genetic variants in OCT1 have been …

Hepatocyte nuclear factor-4α (HNF-4α) is a member of the nuclear receptor superfamily, a
class of ligand-activated transcription factors. A nonsense mutation in the gene encoding this …

OBJECTIVE: The paper aims to explore effective measures and strategies for the promotion
of ICT-enabled innovations for the elderly and people with special needs. METHODS: The …

Transcription factor 7-like 2 (TCF7L2) has been shown to be associated with type 2
diabetes mellitus in multiple ethnic groups. Regarding the Asian population, Horikoshi et al.(…