Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: prominent roles for CYP3A and CYP2D6
Z Desta, BA Ward, NV Soukhova… - Journal of Pharmacology …, 2004 - ASPET
We performed comprehensive kinetic, inhibition, and correlation analyses in human liver
microsomes and experiments in expressed human cytochromes P450 (P450s) to identify …
microsomes and experiments in expressed human cytochromes P450 (P450s) to identify …
Inhibition of cytochrome P450 (CYP450) isoforms by isoniazid: potent inhibition of CYP2C19 and CYP3A
Z Desta, NV Soukhova… - Antimicrobial agents and …, 2001 - Am Soc Microbiol
Isoniazid (INH) remains the most safe and cost-effective drug for the treatment and prophylaxis
of tuberculosis. The use of INH has increased over the past years, largely as a result of …
of tuberculosis. The use of INH has increased over the past years, largely as a result of …
Effect of antipsychotic drugs on human liver cytochrome P-450 (CYP) isoforms in vitro: preferential inhibition of CYP2D6
JG Shin, N Soukhova, DA Flockhart - Drug metabolism and disposition, 1999 - ASPET
The ability of antipsychotic drugs to inhibit the catalytic activity of five cytochrome P-450 (CYP)
isoforms was compared using in vitro human liver microsomal preparations to evaluate …
isoforms was compared using in vitro human liver microsomal preparations to evaluate …
The measurement of free thyroxine by isotope dilution tandem mass spectrometry
SJ Soldin, N Soukhova, N Janicic, J Jonklaas… - Clinica chimica acta, 2005 - Elsevier
BACKGROUND: Most clinical chemistry laboratories measure free thyroxine (FT4) by an
analogue (direct) method. Nevertheless, the validity of analogue FT4 immunoassays has been …
analogue (direct) method. Nevertheless, the validity of analogue FT4 immunoassays has been …
In vitro inhibition of the cytochrome P450 (CYP450) system by the antiplatelet drug ticlopidine: potent effect on CYP2C19 and CYP2D6
JW Ko, Z Desta, NV Soukhova, T Tracy… - British journal of …, 2000 - Wiley Online Library
Aims To examine the potency of ticlopidine (TCL) as an inhibitor of cytochrome P450s (CYP450s)
in vitro using human liver microsomes (HLMs) and recombinant human CYP450s. …
in vitro using human liver microsomes (HLMs) and recombinant human CYP450s. …
Isotope dilution tandem mass spectrometric method for T4/T3
N Soukhova, OP Soldin, SJ Soldin - Clinica Chimica Acta, 2004 - Elsevier
Background: The thyroid hormones thyroxine (T4) and 3,5,3′-triidothyronine (T3) are essential
for regulating a number of biological processes, including growth, neurodevelopment, …
for regulating a number of biological processes, including growth, neurodevelopment, …
Triethylenethiophosphoramide is a specific inhibitor of cytochrome P450 2B6: implications for cyclophosphamide metabolism
Cytochrome P450 2B6 is a genetically polymorphic enzyme that is important in the
metabolism of a number of clinically used drugs. This enzyme is not as well studied as other …
metabolism of a number of clinically used drugs. This enzyme is not as well studied as other …
Studies on the mechanism of a fatal clarithromycin-pimozide interaction in a patient with Tourette syndrome
…, MD Drici, T Kerbusch, N Soukhova… - Journal of clinical …, 2000 - journals.lww.com
The authors report in detail the case of a 27-year-old man who experienced sudden cardiac
death 2 days after coprescription of the neuroleptic pimozide and the macrolide antibiotic …
death 2 days after coprescription of the neuroleptic pimozide and the macrolide antibiotic …
Identification and characterization of human cytochrome P450 isoforms interacting with pimozide
Z Desta, T Kerbusch, N Soukhova, E Richard… - … of Pharmacology and …, 1998 - ASPET
Using human liver microsomes (HLMs) and recombinant human cytochrome P450 (CYP450)
isoforms, we identified the major route of pimozide metabolism, the CYP450 isoforms …
isoforms, we identified the major route of pimozide metabolism, the CYP450 isoforms …
Rapid measurement of plasma acylcarnitines by liquid chromatography–tandem mass spectrometry without derivatization
AK Ghoshal, T Guo, N Soukhova, SJ Soldin - Clinica chimica acta, 2005 - Elsevier
BACKGROUND: Tandem mass spectrometry (MS/MS) is being increasingly used to identify
and measure acylcarnitines in blood and urine of children suspected of having fatty …
and measure acylcarnitines in blood and urine of children suspected of having fatty …