We performed comprehensive kinetic, inhibition, and correlation analyses in human liver
microsomes and experiments in expressed human cytochromes P450 (P450s) to identify …

Isoniazid (INH) remains the most safe and cost-effective drug for the treatment and prophylaxis
of tuberculosis. The use of INH has increased over the past years, largely as a result of …

The ability of antipsychotic drugs to inhibit the catalytic activity of five cytochrome P-450 (CYP)
isoforms was compared using in vitro human liver microsomal preparations to evaluate …

BACKGROUND: Most clinical chemistry laboratories measure free thyroxine (FT4) by an
analogue (direct) method. Nevertheless, the validity of analogue FT4 immunoassays has been …

Aims To examine the potency of ticlopidine (TCL) as an inhibitor of cytochrome P450s (CYP450s)
in vitro using human liver microsomes (HLMs) and recombinant human CYP450s. …

Background: The thyroid hormones thyroxine (T4) and 3,5,3′-triidothyronine (T3) are essential
for regulating a number of biological processes, including growth, neurodevelopment, …

Cytochrome P450 2B6 is a genetically polymorphic enzyme that is important in the
metabolism of a number of clinically used drugs. This enzyme is not as well studied as other …

The authors report in detail the case of a 27-year-old man who experienced sudden cardiac
death 2 days after coprescription of the neuroleptic pimozide and the macrolide antibiotic …

Using human liver microsomes (HLMs) and recombinant human cytochrome P450 (CYP450)
isoforms, we identified the major route of pimozide metabolism, the CYP450 isoforms …

BACKGROUND: Tandem mass spectrometry (MS/MS) is being increasingly used to identify
and measure acylcarnitines in blood and urine of children suspected of having fatty …