Thromboxane A2: physiology/pathophysiology, cellular signal transduction and pharmacology

N Nakahata - Pharmacology & therapeutics, 2008 - Elsevier
… TP is glycosylated in the N-terminal region for recruitment to plasma membranes. Furthermore,
TP conformation is changed by coupling to G proteins, showing several states of agonist …

Inhibition of cyclooxygenase and prostaglandin E2 synthesis by γ-mangostin, a xanthone derivative in mangosteen, in C6 rat glioma cells

K Nakatani, N Nakahata, T Arakawa, H Yasuda… - Biochemical …, 2002 - Elsevier
… The medium was acidified to pH 4.0 by addition of 1 N HCl, and PGE 2 was extracted twice
with ethyl acetate. After ethyl acetate was evaporated under a stream of N 2 gas, the sample …

Nerve growth factor-inducing activity of Hericium erinaceus in 1321N1 human astrocytoma cells

…, S Kinugasa, S Inatomi, N Nakahata - Biological and …, 2008 - jstage.jst.go.jp
… erinaceus extracts was inhibited by the c-jun N-terminal kinase (JNK) inhibitor SP600125.
In addition, H. erinaceus extracts induced phosphorylation of JNK and its downstream …

Inhibitory effect of naringin on lipopolysaccharide (LPS)-induced endotoxin shock in mice and nitric oxide production in RAW 264.7 macrophages

…, T Hiura, Y Osanai, M Ujibe, Y Obara, N Nakahata… - Life Sciences, 2006 - Elsevier
… For intraperitoneal (ip, 20 mg/kg) injection of LPS at 48 h, the survival rate of mice administered
with LPS alone (n=10) or pretreated with NG at 10, 30 and 60 mg/kg (ip) group (n=10) …

Inhibitions of histamine release and prostaglandin E2 synthesis by mangosteen, a Thai medicinal plant

…, K Oosawa, S Shimura, N Nakahata… - Biological and …, 2002 - jstage.jst.go.jp
… To 1 ml of sample, a mixture of 125ml of NaOH (5N), 0.4 g of NaCl and 2.5 ml of n-butanol
was added. Then, the samples were centrifuged at 1000rpm for 3min. The upper organic …

Rap1 potentiates endothelial cell junctions by spatially controlling myosin II activity and actin organization

…, T Moriya, Y Obara, N Nakahata, N Mochizuki - Journal of Cell …, 2013 - rupress.org
… To generate the plasmid encoding human FGD5 with an N-terminal GFP tag, a cDNA
fragment encoding the N-terminal portion (amino acids 1–241) of human FGD5 was amplified by …

The dorsomedial hypothalamic nucleus is not necessary for food‐anticipatory circadian rhythms of behavior, temperature or clock gene expression in mice

…, M Doi, N Hayasaka, N Nakahata… - European Journal of …, 2009 - Wiley Online Library
… Acute induction of DMH mPer1 and mPer2 was N‐methyl‐d‐aspartate (NMDA) receptor‐dependent,
whereas rhythmic expression after 6 days of restricted feeding was not. Thermal …

Effects of Hericium erinaceus on amyloid β (25-35) peptide-induced learning and memory deficits in mice

…, Y Obara, T Moriya, S Inatomi, N Nakahata - Biomedical …, 2011 - jstage.jst.go.jp
The mushroom Hericium erinaceus has been used as a food and herbal medicine since
ancient times in East Asia. It has been reported that H. erinaceus promotes nerve growth factor …

The signaling pathway leading to extracellular signal-regulated kinase 5 (ERK5) activation via G-proteins and ERK5-dependent neurotrophic effects

Y Obara, N Nakahata - Molecular pharmacology, 2010 - ASPET
… Yutaro Obara and Norimichi Nakahata … [Reproduced from Obara Y, Yamauchi A, Takehara
S, Nemoto W, Takahashi M, Stork PJ, and Nakahata N (2009) ERK5 activity is required for …

Involvement of cyclooxygenase-2 in lipopolysaccharide-induced impairment of the newborn cell survival in the adult mouse dentate gyrus

GN Bastos, T Moriya, F Inui, T Katura, N Nakahata - Neuroscience, 2008 - Elsevier
… For BrdU-immunohistochemistry, one group of sections was treated with HCl (2 N) at 37
C for 20 min, followed by neutralization with sodium borate buffer (0.15 M, pH 8.5) at room …