Mediators involved in the generation of symptoms in patients with irritable bowel syndrome (IBS)
are poorly understood. Here we show that colonic biopsy samples from IBS patients …

… the proteolytic cleavage of their N-terminal domain.1, 2, 3 The new N-terminal sequence that
… Values are mean ± SEM, n = 8 per group except for E where n = 6 per group. *, Significantly …

Exacerbated sensitivity to mechanical stimuli that are normally innocuous or mildly painful (mechanical
allodynia and hyperalgesia) occurs during inflammation and underlies painful …

Mast cells (MCs) influence intercellular communication during inflammation by secreting
cytoplasmic granules that contain diverse mediators. Here, we have demonstrated that MCs …

Allergic skin diseases, such as atopic dermatitis, are clinically characterized by severe itching
and type 2 immunity-associated hypersensitivity to widely distributed allergens, including …

Interplay between physiological systems in the body plays a prominent role in health and
disease. At the cellular level, such interplay is orchestrated through the binding of specific …

Visceral pain is the most common reason for doctor visits in the US. Like somatic pain,
virtually all visceral pain sensations begin with the activation of primary sensory neurons …

Lipid autacoids derived from n-3/n-6 polyunsaturated fatty acids (PUFA) are some of the
earliest signals triggered by an inflammatory reaction. They are acting also as essential …

Background and purpose: Protease‐activated receptor‐4 (PAR 4 ), the most recently discovered
member of the PARs family, is activated by thrombin, trypsin and cathepsin G, but can …

BACKGROUND & AIMS: The transient receptor potential vanilloid-4 (TRPV4) is an osmosensitive
channel that responds to mechanical stimulation. We hypothesized that TRPV4 could …