User profiles for N. Byun
Nellie Byun, PhDUS Dept of Health & Human Services Verified email at hhs.gov Cited by 1746 |
[HTML][HTML] Muscarinic and nicotinic acetylcholine receptor agonists and allosteric modulators for the treatment of schizophrenia
Muscarinic and nicotinic acetylcholine (ACh) receptors (mAChRs and nAChRs) are emerging
as important targets for the development of novel treatments for the symptoms associated …
as important targets for the development of novel treatments for the symptoms associated …
Muscarinic receptor pharmacology and circuitry for the modulation of cognition
The muscarinic cholinergic system constitutes an important part of the neuronal circuitry that
modulates normal cognition. Muscarinic receptor antagonists are well known to produce or …
modulates normal cognition. Muscarinic receptor antagonists are well known to produce or …
The K–Cl cotransporter KCC3 is mutant in a severe peripheral neuropathy associated with agenesis of the corpus callosum
… For example, there was no weight difference between the three genotypes at three weeks
(n = 132, analysis of variance (ANOVA) F 2,129 = 2.42, P > 0.05) or eight weeks of age (…
(n = 132, analysis of variance (ANOVA) F 2,129 = 2.42, P > 0.05) or eight weeks of age (…
[PDF][PDF] Biased mGlu5-positive allosteric modulators provide in vivo efficacy without potentiating mGlu5 modulation of NMDAR currents
…, KJ Gregory, PN Vinson, AD Thompson, N Byun… - Neuron, 2015 - cell.com
Schizophrenia is associated with disruptions in N-methyl-D-aspartate glutamate receptor
subtype (NMDAR)-mediated excitatory synaptic signaling. The metabotropic glutamate …
subtype (NMDAR)-mediated excitatory synaptic signaling. The metabotropic glutamate …
A novel selective muscarinic acetylcholine receptor subtype 1 antagonist reduces seizures without impairing hippocampus-dependent learning
…, TM Bridges, Z Xiang, AS Kane, NE Byun… - Molecular …, 2009 - ASPET
… Whole-cell patch-clamp recordings demonstrate that VU0255035 inhibits potentiation of
N-methyl-d-aspartate receptor currents by the muscarinic agonist carbachol in hippocampal …
N-methyl-d-aspartate receptor currents by the muscarinic agonist carbachol in hippocampal …
[HTML][HTML] Antipsychotic drug-like effects of the selective M4 muscarinic acetylcholine receptor positive allosteric modulator VU0152100
… All solutions were adjusted to a pH of approximately 6–7 using 1 N sodium hydroxide
and administered in a volume of 1 ml/kg, with the exception of VU0152100, which was …
and administered in a volume of 1 ml/kg, with the exception of VU0152100, which was …
Novel allosteric agonists of M1 muscarinic acetylcholine receptors induce brain region-specific responses that correspond with behavioral effects in animal models
… Five milliliters of 1 N NaOH was then added and the mixture was vortexed until dissolved.
An additional 5 ml of HBSS/20 mm HEPES was then added. Ten milliliters of probenecid …
An additional 5 ml of HBSS/20 mm HEPES was then added. Ten milliliters of probenecid …
Localization of the kcc4 potassium–chloride cotransporter in the nervous system
Potassium–chloride cotransporters (KCCs) collectively play a crucial role in the function and
development of both the peripheral and central nervous systems. KCC4 is perhaps the least …
development of both the peripheral and central nervous systems. KCC4 is perhaps the least …
Axonal and periaxonal swelling precede peripheral neurodegeneration in KCC3 knockout mice
… N = nucleus. This image reflects one plane of the confocal Z-stack. The asterisk denotes a
… area (axonal densities) is also equivalent between the two genotypes (N = 4 per genotype). …
… area (axonal densities) is also equivalent between the two genotypes (N = 4 per genotype). …
[PDF][PDF] Cholinergic projections to the substantia nigra pars reticulata inhibit dopamine modulation of basal ganglia through the M4 muscarinic receptor
… This DREADD is a modified M4 receptor that no longer binds ACh, but can be selectively
activated by clozapine-N-oxide (CNO), an inactive metabolite of clozapine. Bath application of …
activated by clozapine-N-oxide (CNO), an inactive metabolite of clozapine. Bath application of …