User profiles for N. Byun

Nellie Byun, PhD

US Dept of Health & Human Services
Verified email at hhs.gov
Cited by 1746

[HTML][HTML] Muscarinic and nicotinic acetylcholine receptor agonists and allosteric modulators for the treatment of schizophrenia

CK Jones, N Byun, M Bubser - Neuropsychopharmacology, 2012 - nature.com
Muscarinic and nicotinic acetylcholine (ACh) receptors (mAChRs and nAChRs) are emerging
as important targets for the development of novel treatments for the symptoms associated …

Muscarinic receptor pharmacology and circuitry for the modulation of cognition

M Bubser, N Byun, MR Wood, CK Jones - Muscarinic receptors, 2012 - Springer
The muscarinic cholinergic system constitutes an important part of the neuronal circuitry that
modulates normal cognition. Muscarinic receptor antagonists are well known to produce or …

The K–Cl cotransporter KCC3 is mutant in a severe peripheral neuropathy associated with agenesis of the corpus callosum

HC Howard, DB Mount, D Rochefort, N Byun, N Dupré… - Nature …, 2002 - nature.com
… For example, there was no weight difference between the three genotypes at three weeks
(n = 132, analysis of variance (ANOVA) F 2,129 = 2.42, P > 0.05) or eight weeks of age (…

[PDF][PDF] Biased mGlu5-positive allosteric modulators provide in vivo efficacy without potentiating mGlu5 modulation of NMDAR currents

…, KJ Gregory, PN Vinson, AD Thompson, N Byun… - Neuron, 2015 - cell.com
Schizophrenia is associated with disruptions in N-methyl-D-aspartate glutamate receptor
subtype (NMDAR)-mediated excitatory synaptic signaling. The metabotropic glutamate …

A novel selective muscarinic acetylcholine receptor subtype 1 antagonist reduces seizures without impairing hippocampus-dependent learning

…, TM Bridges, Z Xiang, AS Kane, NE Byun… - Molecular …, 2009 - ASPET
… Whole-cell patch-clamp recordings demonstrate that VU0255035 inhibits potentiation of
N-methyl-d-aspartate receptor currents by the muscarinic agonist carbachol in hippocampal …

[HTML][HTML] Antipsychotic drug-like effects of the selective M4 muscarinic acetylcholine receptor positive allosteric modulator VU0152100

NE Byun, M Grannan, M Bubser, RL Barry… - …, 2014 - nature.com
… All solutions were adjusted to a pH of approximately 6–7 using 1 N sodium hydroxide
and administered in a volume of 1 ml/kg, with the exception of VU0152100, which was …

Novel allosteric agonists of M1 muscarinic acetylcholine receptors induce brain region-specific responses that correspond with behavioral effects in animal models

…, M Bubser, TJ Utley, AG Walker, NE Byun… - Journal of …, 2012 - Soc Neuroscience
… Five milliliters of 1 N NaOH was then added and the mixture was vortexed until dissolved.
An additional 5 ml of HBSS/20 mm HEPES was then added. Ten milliliters of probenecid …

Localization of the kcc4 potassium–chloride cotransporter in the nervous system

MF Karadsheh, N Byun, DB Mount, E Delpire - Neuroscience, 2004 - Elsevier
Potassium–chloride cotransporters (KCCs) collectively play a crucial role in the function and
development of both the peripheral and central nervous systems. KCC4 is perhaps the least …

Axonal and periaxonal swelling precede peripheral neurodegeneration in KCC3 knockout mice

N Byun, E Delpire - Neurobiology of disease, 2007 - Elsevier
N = nucleus. This image reflects one plane of the confocal Z-stack. The asterisk denotes a
… area (axonal densities) is also equivalent between the two genotypes (N = 4 per genotype). …

[PDF][PDF] Cholinergic projections to the substantia nigra pars reticulata inhibit dopamine modulation of basal ganglia through the M4 muscarinic receptor

MS Moehle, T Pancani, N Byun, SE Yohn, GH Wilson… - Neuron, 2017 - cell.com
… This DREADD is a modified M4 receptor that no longer binds ACh, but can be selectively
activated by clozapine-N-oxide (CNO), an inactive metabolite of clozapine. Bath application of …