User profiles for N. J. Parrott

Neil Parrott

Modeling and simulation scientist, F. Hoffmann-LaRoche
Verified email at roche.com
Cited by 6122

[HTML][HTML] A novel orally available small molecule that inhibits hepatitis B virus expression

…, P Tropberger, G Ottaviani, W Lu, NJ Parrott… - Journal of …, 2018 - Elsevier
Background & Aims The hallmarks of chronic HBV infection are a high viral load (HBV DNA)
and even higher levels (>100-fold in excess of virions) of non-infectious membranous …

Advancing Predictions of Tissue and Intracellular Drug Concentrations Using In Vitro, Imaging and Physiologically Based Pharmacokinetic Modeling Approaches

Y Guo, X Chu, NJ Parrott, KLR Brouwer… - Clinical …, 2018 - Wiley Online Library
This white paper examines recent progress, applications, and challenges in predicting
unbound and total tissue and intra/subcellular drug concentrations using in vitro and preclinical …

[HTML][HTML] Metabolic Profiling of Human Long-Term Liver Models and Hepatic Clearance Predictions from In Vitro Data Using Nonlinear Mixed-Effects Modeling

…, H Javanbakht, C Funk, F Schuler, T Lavé, NJ Parrott - The AAPS journal, 2017 - Springer
Early prediction of human clearance is often challenging, in particular for the growing
number of low-clearance compounds. Long-term in vitro models have been developed which …

Pharmacology of basimglurant (RO4917523, RG7090), a unique metabotropic glutamate receptor 5 negative allosteric modulator in clinical development for …

…, C Funk, A Gloge, M Schneider, NJ Parrott… - … of Pharmacology and …, 2015 - ASPET
Major depressive disorder (MDD) is a serious public health burden and a leading cause of
disability. Its pharmacotherapy is currently limited to modulators of monoamine …

Simulation-based evaluation of PK/PD indices for meropenem across patient groups and experimental designs

AN Kristoffersson, P David-Pierson, NJ Parrott… - Pharmaceutical …, 2016 - Springer
Purpose Antibiotic dose predictions based on PK/PD indices rely on that the index type and
magnitude is insensitive to the pharmacokinetics (PK), the dosing regimen, and bacterial …

Dissolution media simulating the proximal canine gastrointestinal tract in the fasted state

M Arndt, H Chokshi, K Tang, NJ Parrott… - European Journal of …, 2013 - Elsevier
Human biorelevant media have been shown to be a useful tool in pharmaceutical development
and to provide input for in silico prediction of pharmacokinetic profiles after oral dosing. …

A fast virtual screening filter for cytochrome P450 3A4 inhibition liability of compound libraries

…, U Fechner, O Roche, NJ Parrott… - Quantitative …, 2002 - Wiley Online Library
Current virtual screening applications focus not only on biological activity, but also on
additional relevant properties of drug candidates, like absorption, distribution, metabolism, and …

[HTML][HTML] Impact of target interactions on small-molecule drug disposition: an overlooked area

RAB van Waterschoot, NJ Parrott… - Nature reviews Drug …, 2018 - nature.com
Dose of drug the endothelin receptor antagonist bosentan, the angiotensin-converting enzyme
inhibitor enalaprilat, the aldose reductase inhibitor imirestat, the dipeptidyl peptidase 4 …

Physiologically based absorption modeling to explore the impact of food and gastric pH changes on the pharmacokinetics of alectinib

NJ Parrott, LJ Yu, R Takano, M Nakamura, PN Morcos - The AAPS journal, 2016 - Springer
Alectinib, a lipophilic, basic, anaplastic lymphoma kinase (ALK) inhibitor with very low
aqueous solubility, has received Food and Drug Administration-accelerated approval for the …

Importance of target-mediated drug disposition for small molecules

DA Smith, RA Van Waterschoot, NJ Parrott… - Drug discovery today, 2018 - Elsevier
Highlights • Target-mediated drug disposition for small molecules is not addressed systematically.
• TMDD has a major influence on drug distribution and clearance. • TMDD results in …