Pharmacological effects of Lu AA21004: a novel multimodal compound for the treatment of major depressive disorder

…, AB Lassen, S Miller, L Westrich, NJ Boyle… - … of Pharmacology and …, 2012 - ASPET
1-[2-(2,4-Dimethylphenyl-sulfanyl)-phenyl]-piperazine (Lu AA21004) is a human (h) serotonin
(5-HT) 3A receptor antagonist (K i = 3.7 nM), h5-HT 7 receptor antagonist (K i = 19 nM), h5-…

[HTML][HTML] Burnout, moral distress, work–life balance, and career satisfaction among hematopoietic cell transplantation professionals

…, S Virani, EM Denzen, DA Boyle, NJ Boyle… - Biology of Blood and …, 2018 - Elsevier
A projected shortage of hematopoietic cell transplantation (HCT) health professionals was
identified as a major issue during the National Marrow Donor Program/Be The Match System …

Binding of vascular heparan sulfate proteoglycan to Alzheimer's amyloid precursor protein is mediated in part by the N-terminal region of A4 peptide

…, S Narindrasorasak, R Kisilevsky, NJ Boyle… - Brain research, 1993 - Elsevier
The exact mechanisms of deposition and accumulation of amyloid in senile plaques and in
blood vessels in Alzheimer's disease remain unknown. Heparan sulfate proteoglycans may …

An allosteric binding site at the human serotonin transporter mediates the inhibition of escitalopram by R-citalopram: Kinetic binding studies with the ALI/VFL–SI/TT …

H Zhong, KB Hansen, NJ Boyle, K Han, G Muske… - Neuroscience …, 2009 - Elsevier
The human serotonin transporter (hSERT) has primary and allosteric binding sites for
escitalopram and R-citalopram. Previous studies have established that the interaction of these two …

Benefits of retroequatorial four horizontal muscle recession surgery in congenital idiopathic nystagmus in adults

NJ Boyle, ELM Dawson, JP Lee - Journal of American Association for …, 2006 - Elsevier
… Muscles were sutured directly onto the sclera with 6-0 Vicryl (Ethicon, Somerville, NJ). In
earlier patients the medial rectus was recessed 8 mm and the lateral rectus was recessed 10 …

Blindsight in children: does it exist and can it be used to help the child? Observations on a case series

NJ Boyle, DH Jones, R Hamilton… - … Medicine & Child …, 2005 - Wiley Online Library
Damage to the occipital lobe of the brain results in hemianopia when unilateral, and cerebral
blindness when bilateral. However, in some cases a degree of visual function persists in …

Optimization of an alcian blue dot-blot assay for the detection of glycosaminoglycans and proteoglycans

L Buee, NJ Boyle, L Zhang, A Delacourte, HM Fillit - Analytical biochemistry, 1991 - Elsevier
A modification of a method for the detection of proteoglycans on positively charged nylon
was adapted for use in a dot-blot assay and improved. Different dot-blot membranes were …

[HTML][HTML] Lipomobilization in periparturient dairy cows influences the composition of plasma nonesterified fatty acids and leukocyte phospholipid fatty acids

GA Contreras, NJ O'boyle, TH Herdt, LM Sordillo - Journal of dairy science, 2010 - Elsevier
The periparturient period is characterized by sudden changes in metabolic and immune cell
functions that predispose dairy cows to increased incidence of disease. Metabolic changes …

N-Heteroaryl glycinamides and glycinamines as potent NPY5 antagonists

…, K Andersen, G Chandrasena, NJ Boyle… - Bioorganic & medicinal …, 2011 - Elsevier
Subtype specific ligands are needed to evaluate the therapeutic potential of modulating the
brain’s neuropeptide Y system. The benzothiazepine glycinamide 1a was identified as an …

[HTML][HTML] Changes in glucose transporter expression in monocytes of periparturient dairy cows

NJ O'Boyle, GA Contreras, SA Mattmiller… - Journal of dairy …, 2012 - Elsevier
The transition period of dairy cows is characterized by dramatic changes in metabolism and
immune cell function that contributes to increased susceptibility to several economically …