… Neil H Shear … Correspondence to: Dr Neil H Shear, Sunnybrook & Women's College Health
Sciences Centre, Sunnybrook Site. Division of Clinical Pharmacology E240, Toronto, Ontario …

Although the anticonvulsant hypersensitivity syndrome was first described in 1950,
confusion still abounds regarding the syndrome. The triad of fever, rash and internal organ …

OBJECTIVE: To review reported cases of hyponatremia and the syndrome of inappropriate
secretion of antidiuretic hormone (SIADH) associated with the use of selective serotonin …

• Background and Design.— To conduct a prospective case-control study about causative
factors of severe bullous erythema multiforme, Stevens-Johnson syndrome, and toxic …

Arene oxide metabolites of aromatic anticonvulsants (phenytoin, phenobarbital, and
carbamazepine) may be involved in the pathogenesis of hypersensitivity reactions. We investigated …

Background Drug‐induced hypersensitivity syndrome (DIHS) is an adverse reaction with
clinical signs of fever, rash and internal organ involvement. In the vast majority of patients in …

Drug hypersensitivity syndrome (DHS) is a severe idiosyncratic reaction associated with
drug therapy. Cutaneous eruptions are the most common idiosyncratic reaction to drugs, but …

Individual differences in metabolism of the sulfonamides may predispose patients to idiosyncratic
reactions. Sulfonamides are metabolized by N-acetylation (mediated by a genetically …

The objective of this study is to identify gender‐related differences in the types of symptoms
and drugs reported to cause an adverse drug reaction. Patient data from the Sunnybrook …

The last decade has witnessed remarkable advances in the therapy for cutaneous fungal
diseases. These will have a major impact on the choice of antifungal therapy. To understand …