Effect of repeated administration of TRK-820, a κ-opioid receptor agonist, on tolerance to its antinociceptive and sedative actions
T Suzuki, N Izumimoto, Y Takezawa, M Fujimura… - Brain research, 2004 - Elsevier
Repeated administration of μ-opioid receptor agonist, morphine induces tolerance not only
to the antinociceptive effect but also to other pharmacological effects, resulting in shortened …
to the antinociceptive effect but also to other pharmacological effects, resulting in shortened …
Restraint stress-induced changes in endogenous zinc release from the rat hippocampus
T Itoh, T Saito, M Fujimura, S Watanabe, K Saito - Brain Research, 1993 - Elsevier
Abstract Changes in the levels of endogenous zinc and amino acids released from rat
hippocampus due to one-hour restraint stress were measured using brain microdialysis. The zinc …
hippocampus due to one-hour restraint stress were measured using brain microdialysis. The zinc …
Characteristics of TRK-130 (Naltalimide), a novel opioid ligand, as a new therapeutic agent for overactive bladder
M Fujimura, N Izumimoto, S Momen… - … of Pharmacology and …, 2014 - ASPET
We characterized TRK-130 (N-[(5R,6R,14S)-17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-yl]phthalimide;
naltalimide), an opioid ligand, to clarify the therapeutic …
naltalimide), an opioid ligand, to clarify the therapeutic …
Age-dependent and region-specific differences in the distribution of trace elements in 7 brain regions of Long-Evans Cinnamon (LEC) rats with hereditary abnormal …
T Saito, T Itoh, M Fujimura, K Saito - Brain research, 1995 - Elsevier
Cu, Mn, Mo, Rb and Zn concentrations of 7 brain regions in LEC rats were determined
before (4 and 10 weeks old) and after (20 weeks old) the onset of jaundice. Cu in the LEC rat …
before (4 and 10 weeks old) and after (20 weeks old) the onset of jaundice. Cu in the LEC rat …
Mechanisms of inhibitory action of TRK-130 (Naltalimide), a μ-opioid receptor partial agonist, on the micturition reflex
M Fujimura, N Izumimoto, S Kanie, R Kobayashi… - … urology and nephrology, 2017 - Springer
Purpose To clarify the mechanism of inhibitory action of TRK-130 (Naltalimide), a unique µ-opioid
receptor partial agonist, on the micturition reflex. Methods The effect of TRK-130 on …
receptor partial agonist, on the micturition reflex. Methods The effect of TRK-130 on …
[PDF][PDF] A next generation drug for overactive bladder, TRK-130, in a Phase-IIb clinical trial in Japan; Preclinical data of potent pharmacological effects based on …
K Kawai, M Fujimura, S Kanie, N Izumimoto, M Hirakata… - Delta, 2011 - ics.org
Hypothesis/aim of study It is well-known that opioidergic modulation is involved in the control
of the voiding pathway through spinal and supraspinal mechanisms (1); therefore, opioid …
of the voiding pathway through spinal and supraspinal mechanisms (1); therefore, opioid …
[HTML][HTML] Systemic and intrathecal baclofen produce bladder antinociception in rats
TJ Ness, A Randich, X Su, C DeWitte, K Hildebrand - BMC urology, 2021 - Springer
Background Baclofen, a clinically available GABA B receptor agonist, produces non-opioid
analgesia in multiple models of pain but has not been tested for effects on bladder …
analgesia in multiple models of pain but has not been tested for effects on bladder …
[PDF][PDF] And Experimental Therapeutics
MC Michel, LM Howells, J Mahale, S Sale, L McVeigh… - academia.edu
PHARMACOLOGY Page 1 The Journal of PHARMACOLOGY And Experimental Therapeutics
A Publication of the American Society for Pharmacology and Experimental Therapeutics …
A Publication of the American Society for Pharmacology and Experimental Therapeutics …
Synthesis of Bi (FexAl1-x) O3 thin films by pulsed laser deposition and its structural characterization
…, T Yoshimura, A Ashida, N Fujimura - Japanese journal of …, 2004 - iopscience.iop.org
We have been attempting to synthesize perovskite BiAlO 3 as a new lead-free piezoelectric
material. No indication of the formation of the BiAlO 3 phase by the bulk ceramic processing …
material. No indication of the formation of the BiAlO 3 phase by the bulk ceramic processing …
[BOOK][B] Speech production and language: In honor of Osamu Fujimura
S Kiritani, H Hirose, H Fujisaki - 2013 - books.google.com
This book is a collection of research papers written in honor of Osamu Fujimura by his friends
and pupils. It recognizes Osamu Fujimura's own outstanding contributions and leadership …
and pupils. It recognizes Osamu Fujimura's own outstanding contributions and leadership …