IRS‐1 undergoes rapid tyrosine phosphorylation during insulin stimulation and forms a
stable complex containing the 85 kDa subunit (p85) of the phosphatidylinositol (PtdIns) 3′‐…

IRS-1 (insulin receptor substrate 1) is a principal insulin receptor substrate that undergoes
tyrosine phosphorylation during insulin stimulation. It contains over 20 potential tyrosine …

Insulin rapidly stimulates tyrosine phosphorylation of a protein of approximately 185 kD in
most cell types. This protein, termed insulin receptor substrate-1 (IRS-1), has been implicated …

Aclidinium bromide is a novel, long-acting inhaled muscarinic antagonist drug in Phase III
clinical trials for chronic obstructive pulmonary disease (COPD). The aims of this study were to …

Phosphatidylinositol 3-kinase (PI-3 kinase) is implicated in the regulation of diverse cellular
processes, including insulin-stimulated glucose transport. PI-3 kinase is composed of a 110-…

Aclidinium bromide is a novel potent, long-acting inhaled muscarinic antagonist in
development for the treatment of chronic obstructive pulmonary disease. Aclidinium showed …

Background Sensory nerves innervating the airways play an important role in regulating
various cardiopulmonary functions, maintaining homeostasis under healthy conditions and …

A series of 3,4-diaryloxazolones were prepared and evaluated for their ability to inhibit
cyclooxygenase-2 (COX-2). Extensive structure−activity relationship work was carried out within …

The objective of this work was to discover a novel, long-acting muscarinic M 3 antagonist for
the inhaled treatment of chronic obstructive pulmonary disease (COPD), with a potentially …

A common pharmacophore for compounds structurally related to nitraquazone has been
derived. Using this pharmacophore, new structures have been designed, synthesized, and …