User profiles for Mohsen Badiee
Mohsen BadieeJohns Hopkins University Verified email at jhu.edu Cited by 509 |
The DarTG toxin-antitoxin system provides phage defence by ADP-ribosylating viral DNA
Toxin-antitoxin (TA) systems are broadly distributed, yet poorly conserved, genetic elements
whose biological functions are unclear and controversial. Some TA systems may provide …
whose biological functions are unclear and controversial. Some TA systems may provide …
[PDF][PDF] Poly (ADP-ribose) drives condensation of FUS via a transient interaction
Poly(ADP-ribose) (PAR) is an RNA-like polymer that regulates an increasing number of
biological processes. Dysregulation of PAR is implicated in neurodegenerative diseases …
biological processes. Dysregulation of PAR is implicated in neurodegenerative diseases …
[HTML][HTML] Molecular pharmacodynamics of emixustat in protection against retinal degeneration
Emixustat is a visual cycle modulator that has entered clinical trials as a treatment for age-related
macular degeneration (AMD). This molecule has been proposed to inhibit the visual …
macular degeneration (AMD). This molecule has been proposed to inhibit the visual …
Catalytic mechanism of a retinoid isomerase essential for vertebrate vision
Visual function in vertebrates is dependent on the membrane-bound retinoid isomerase
RPE65, an essential component of the retinoid cycle pathway that regenerates 11-cis-retinal for …
RPE65, an essential component of the retinoid cycle pathway that regenerates 11-cis-retinal for …
Switch-like compaction of poly (ADP-ribose) upon cation binding
Poly(ADP-ribose) (PAR) is a homopolymer of adenosine diphosphate ribose that is added
to proteins as a posttranslational modification to regulate numerous cellular processes. PAR …
to proteins as a posttranslational modification to regulate numerous cellular processes. PAR …
Both ADP-ribosyl-binding and hydrolase activities of the alphavirus nsP3 macrodomain affect neurovirulence in mice
Macrodomain (MD), a highly conserved protein fold present in a subset of plus-strand RNA
viruses, binds to and hydrolyzes ADP-ribose (ADPr) from ADP-ribosylated proteins. ADPr-…
viruses, binds to and hydrolyzes ADP-ribose (ADPr) from ADP-ribosylated proteins. ADPr-…
Tuning the Metabolic Stability of Visual Cycle Modulators through Modification of an RPE65 Recognition Motif
…, J Zaluski, B Li, J Zhang, M Badiee… - Journal of medicinal …, 2023 - ACS Publications
In the eye, the isomerization of all-trans-retinal to 11-cis-retinal is accomplished by a metabolic
pathway termed the visual cycle that is critical for vision. RPE65 is the essential trans–cis …
pathway termed the visual cycle that is critical for vision. RPE65 is the essential trans–cis …
Structure and spectroscopy of alkene-cleaving dioxygenases containing an atypically coordinated non-heme iron center
Carotenoid cleavage oxygenases (CCOs) are non-heme iron enzymes that catalyze scission
of alkene groups in carotenoids and stilbenoids to form biologically important products. …
of alkene groups in carotenoids and stilbenoids to form biologically important products. …
Retinoid isomerase inhibitors impair but do not block mammalian cone photoreceptor function
…, JM Angueyra, AV Kolesnikov, M Badiee… - Journal of General …, 2018 - rupress.org
Visual function in vertebrates critically depends on the continuous regeneration of visual
pigments in rod and cone photoreceptors. RPE65 is a well-established retinoid isomerase in …
pigments in rod and cone photoreceptors. RPE65 is a well-established retinoid isomerase in …
Rational tuning of visual cycle modulator pharmacodynamics
Modulators of the visual cycle have been developed for treatment of various retinal disorders.
These agents were designed to inhibit retinoid isomerase [retinal pigment epithelium-…
These agents were designed to inhibit retinoid isomerase [retinal pigment epithelium-…