The clinical impact of the fibrate and thiazolidinedione drugs on dyslipidemia and diabetes
is driven mainly through activation of two transcription factors, peroxisome proliferator-…

A new chemical class of potent DPP-4 inhibitors structurally derived from the xanthine
scaffold for the treatment of type 2 diabetes has been discovered and evaluated. Systematic …

BI 1356 [proposed trade name ONDERO; (R)-8-(3-amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione]
is a novel dipeptidyl …

Inhibition of fatty acid synthase (FAS) reduces food intake in rodents. As adipose tissue
expresses FAS, we sought to investigate the effect of reduced FAS activity on adipocyte …

Long-chain saturated fatty acids are cytotoxic to pancreatic β-cells while shorter-chain
saturated and long-chain unsaturated molecules are better tolerated. Mono-unsaturated fatty …

… Author links open overlay panel Matthias Eckhardt a , Norbert Hauel a , Frank Himmelsbach
a , Elke Langkopf a , Herbert Nar b , Michael Mark c , Moh Tadayyon c , Leo Thomas c …

Antidiabetic effects of dipeptidyl peptidase-4 (DPP-4) inhibitors are exerted by potentiation
of the biological activity of incretin hormones like glucagon-like peptide (GLP)-1. BI 1356 […

Saturated and mono-unsaturated fatty acids exert differential effects on pancreatic β-cell
viability during chronic exposure. Long chain saturated molecules (eg palmitate) are cytotoxic to …

Rosiglitazone is an agonist of peroxisome proliferator activated receptor‐γ (PPARγ) and
ameliorates insulin resistance in type II diabetes. In addition, it may also promote increased …

Although the list of clinical complications associated with HIV therapy continues to grow, the
underlying mechanisms remain incompletely understood. Metabolic abnormalities, such as …