The α v β 3 integrin is expressed on proliferating endothelial cells such as those present in
growing tumors, as well as on tumor cells of various origin. Tumor-induced angiogenesis can …

Objective— Proteases are emerging biomarkers of inflammatory diseases. In atherosclerosis,
these enzymes are often secreted by inflammatory macrophages, digest the extracellular …

Carbonic anhydrase IX (CA IX) is a transmembrane protein that has been shown to be
greatly upregulated under conditions of hypoxia in many tumor cell lines. Tumor hypoxia is …

Purpose Integrins, especially α v β 3 and α v β 5 , are upregulated in tumor cells and activated
endothelial cells and as such, serve as cancer biomarkers. We developed a novel near-…

A number of spiro[indoline‐3,2′‐thiazolidine]‐2,4′‐diones have been prepared via the
cyclocondensation of isatin‐3‐imines with α‐mercaptoacids. 1‐Benzyl‐5′,5′‐dimethylspiro[…

A series of human carbonic anhydrase (hCA) IX inhibitors conjugated to various near-infrared
fluorescent dyes was synthesized with the aim of imaging hypoxia-induced hCA IX …

Hydrazones of a 6-hydrazinonicotinyl-modified cyclic peptide IIb/IIIa receptor antagonist
were prepared in order to protect the hydrazine moiety from reaction with trace aldehyde and …

We developed a neutrophil elastase-specific near-infrared fluorescence imaging agent,
which, combined with fluorescence molecular tomographic imaging, allowed us to detect and …

The 90 Y and 177 Lu complexes (RP697 and RP688, respectively) of a DOTA-conjugated
vitronectin receptor antagonist (SU015: 2-(1,4,7,10-tetraaza-4,7,10-tris(carboxymethyl)-1-…

Arginine-glycine-aspartic acid (RGD) peptides preferentially bind to α v β 3 integrin, an integrin
expressed on newly formed endothelial cells and on various tumor cells. When labeled …