Platelet endothelial cell adhesion molecule-1 signaling inhibits the activation of human platelets

M Cicmil, JM Thomas, M Leduc, C Bon… - Blood, The Journal of …, 2002 - ashpublications.org
Platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) is a 130-kd transmembrane
glycoprotein and a member of the growing family of receptors with immunoreceptor tyrosine-…

[HTML][HTML] Collagen, convulxin, and thrombin stimulate aggregation-independent tyrosine phosphorylation of CD31 in platelets: evidence for the involvement of Src …

M Cicmil, JM Thomas, T Sage, FA Barry… - Journal of Biological …, 2000 - ASBMB
Platelet endothelial cell adhesion molecule-1 (CD31) is a 130-kDa glycoprotein receptor
present on the surface of platelets, neutrophils, monocytes, certain T-lymphocytes, and vascular …

Mineralocorticoid receptor antagonists attenuate pulmonary inflammation and bleomycin-evoked fibrosis in rodent models

…, MA Gil, S Keshwani, JD Woodhouse, M Cicmil… - European journal of …, 2013 - Elsevier
Accumulating evidence indicates protective actions of mineralocorticoid antagonists (MR
antagonists) on cardiovascular pathology, which includes blunting vascular inflammation and …

Preclinical experimental and mathematical approaches for assessing effective doses of inhaled drugs, using mometasone to support human dose predictions

…, N Johnson, M Salmon, M Cicmil - Journal of aerosol …, 2016 - liebertpub.com
Background: Understanding the relationship between dose, lung exposure, and drug
efficacy continues to be a challenging aspect of inhaled drug development. An experimental …

[HTML][HTML] Development and optimization of a high-throughput micro-computed tomography imaging method incorporating a novel analysis technique to evaluate bone …

…, E Leccese, D Conway, LY Moy, B Dogdas, M Cicmil… - Bone, 2015 - Elsevier
Rheumatoid arthritis (RA) is a chronic autoimmune disease resulting in joint inflammation,
pain, and eventual bone loss. Bone loss and remodeling caused by symmetric polyarthritis, …

The preclinical efficacy, selectivity and pharmacologic profile of MK-5932, an insulin-sparing selective glucocorticoid receptor modulator

…, P Bunting, A Byford, CS Chiu, M Cicmil… - European Journal of …, 2014 - Elsevier
Glucocorticoids are used widely in the treatment of inflammatory diseases, but use is
accompanied by a significant burden of adverse effects. It has been hypothesized that gene- and …

[HTML][HTML] Etanercept ameliorates inflammation and pain in a novel mono-arthritic multi-flare model of streptococcal cell wall induced arthritis

…, D Stoffregen, W Zhang, A Murtaza, M Cicmil - BMC Musculoskeletal …, 2014 - Springer
Background The impact of anti-TNF, corticosteroid and analgesic therapy on inflammation
and pain was evaluated in a novel mono-arthritic multi-flare rat Streptococcal Cell Wall (SCW) …

[HTML][HTML] Anti-inflammatory actions of chemoattractant receptor-homologous molecule expressed on Th2 by the antagonist MK-7246 in a novel rat model of Alternaria …

…, J Zhang-Hoover, RL McLeod, M Cicmil - European Journal of …, 2014 - Elsevier
Alternaria alternata is a fungal allergen linked to the development of severe asthma in
humans. In view of the clinical relationship between A. alternata and asthma, we sought to …

Multimodal Imaging Reveals that Sustained Inhibition of HIF-Prolyl Hydroxylases Induces Opposing Effects on Right and Left Ventricular Function in Healthy Rats

…, R Sevilla, A Vanko, C Sinz, M Cicmil… - Molecular Imaging and …, 2024 - Springer
Purpose Hypoxia-inducible factor (HIF) drives transcription of critical hypoxia response genes,
increasing the production of red blood cells in low oxygen conditions. In the absence of …

[HTML][HTML] Analysis of cell‐specific peripheral blood biomarkers in severe allergic asthma identifies innate immune dysfunction

…, A Bailey, R de Waal Malefyt, M Cicmil… - Clinical and …, 2022 - ncbi.nlm.nih.gov
To the editor, Asthma is a common chronic airways disease with complex aetiology, having
no single causative genetic trigger and with multiple factors appearing to contribute to …