Synthesis and structure–activity relationships of 1-phenylpyrazoles as xanthine oxidase inhibitors
…, T Ikebe, H Inoue, A Fukunari, M Kamezawa… - Bioorganic & medicinal …, 2001 - Elsevier
A series of 1-phenylpyrazoles was evaluated for inhibitory activity against xanthine oxidase
in vitro. Of the compounds prepared, 1-(3-cyano-4-neopentyloxyphenyl)pyrazole-4-…
in vitro. Of the compounds prepared, 1-(3-cyano-4-neopentyloxyphenyl)pyrazole-4-…
Y-700 [1-[3-Cyano-4-(2, 2-dimethylpropoxy) phenyl]-1H-pyrazole-4-carboxylic acid]: a potent xanthine oxidoreductase inhibitor with hepatic excretion
…, T Nishino, BT Eger, EF Pai, M Kamezawa… - … of Pharmacology and …, 2004 - ASPET
… Pai, Miho Kamezawa, Ichimaro Yamada and Norihisa Kato … Ishibuchi S, Morimoto H, Oe
T, Ikebe T, Inoue H, Fukunari A, Kamezawa M, Yamada I, and Naka Y (2001) Synthesis and …
T, Ikebe T, Inoue H, Fukunari A, Kamezawa M, Yamada I, and Naka Y (2001) Synthesis and …
Utility of bilirubins and bile acids as endogenous biomarkers for the inhibition of hepatic transporters
T Watanabe, M Miyake, T Shimizu, M Kamezawa… - Drug Metabolism and …, 2015 - ASPET
It is useful to identify endogenous substrates for the evaluation of drug-drug interactions via
transporters. In this study, we investigated the utility of bilirubins, substrates of OATPs and …
transporters. In this study, we investigated the utility of bilirubins, substrates of OATPs and …
[HTML][HTML] Plasma pharmacokinetics and synovial concentrations of S-flurbiprofen plaster in humans
I Yataba, N Otsuka, I Matsushita, M Kamezawa… - European journal of …, 2016 - Springer
Purpose The purpose of this study is to investigate the pharmacokinetics and deep tissue
penetration capability of the newly developed S-flurbiprofen plaster (SFPP) in humans. …
penetration capability of the newly developed S-flurbiprofen plaster (SFPP) in humans. …
[HTML][HTML] S (+)-flurbiprofen shows potent PGE2 inhibitory activity in inflammatory cells, superior cell transport activity and skin permeability
Y Toda, M Sugimoto, H Endo, M Kamezawa… - Pharmacology & …, 2016 - scirp.org
We developed a novel topical non-steroidal anti-inflammatory drug (NSAID)patch, S(+)-flurbiprofen
plaster, (SFPP), containing S(+)-flurbiprofen (SFP), an enantiomer of flurbiprofen (FP)…
plaster, (SFPP), containing S(+)-flurbiprofen (SFP), an enantiomer of flurbiprofen (FP)…
Key determinants of the circulatory exposure of organic anions: differences in hepatic uptake between multidrug resistance-associated protein 2 (Mrp2)-deficient rats …
K Kosaka, T Watanabe, T Susukida, S Aoki, S Sekine… - Xenobiotica, 2015 - Taylor & Francis
Full article: Key determinants of the circulatory exposure of organic anions: differences in
hepatic uptake between multidrug resistance-associated protein 2 (Mrp2)-deficient rats and wild…
hepatic uptake between multidrug resistance-associated protein 2 (Mrp2)-deficient rats and wild…
Melanogenic effect of dersimelagon (MT‐7117), a novel oral melanocortin 1 receptor agonist
T Suzuki, Y Kawano, A Matsumoto… - Skin Health and …, 2022 - Wiley Online Library
Background The activation of melanocortin 1 receptor (MC1R) on melanocytes stimulates
the production of eumelanin. A tridecapeptide α melanocyte‐stimulating hormone (αMSH) is …
the production of eumelanin. A tridecapeptide α melanocyte‐stimulating hormone (αMSH) is …
Absorption, metabolism, and excretion of [14C]dersimelagon, an investigational oral selective melanocortin 1 receptor agonist, in preclinical species and healthy …
M Tsuda, K Ogawa, T Endou, T Goto… - Pharmacology …, 2023 - Wiley Online Library
Dersimelagon (formerly MT‐7117) is a novel, orally administered nonpeptide small molecule
selective agonist for melanocortin 1 receptor currently being investigated for the treatment …
selective agonist for melanocortin 1 receptor currently being investigated for the treatment …
Osteopontin transgenic mice fed a high-cholesterol diet develop early fatty-streak lesions
K Isoda, Y Kamezawa, M Ayaori, M Kusuhara, N Tada… - Circulation, 2003 - Am Heart Assoc
Background— Osteopontin (OPN) is a noncollagenous adhesion protein found at the site of
atherosclerotic lesions. However, it has not yet been clarified whether or not OPN can …
atherosclerotic lesions. However, it has not yet been clarified whether or not OPN can …
Osteopontin plays an important role in the development of medial thickening and neointimal formation
K Isoda, K Nishikawa, Y Kamezawa, M Yoshida… - Circulation …, 2002 - Am Heart Assoc
Osteopontin (OPN) is a soluble secreted phosphoprotein that binds with high affinity to several
integrins and it has been found at the site of atherosclerotic lesions. However, the role of …
integrins and it has been found at the site of atherosclerotic lesions. However, the role of …