Pharmacological and pharmacokinetic characterization of the cannabinoid receptor 2 agonist, GW405833, utilizing rodent models of acute and chronic pain, anxiety …
…, SL Gottshall, L Mark, MS Pearson, W Miller, S Shan… - …, 2005 - Elsevier
To date, two cannabinoid receptors have been identified, CB1 and CB2. Activation of these
receptors with non-selective cannabinoid receptor agonists reduces pain sensitivity in …
receptors with non-selective cannabinoid receptor agonists reduces pain sensitivity in …
A role for cannabinoid receptors, but not endogenous opioids, in the antinociceptive activity of the CB2-selective agonist, GW405833
…, SM Chaffer, JE Harrison, MS Pearson… - European journal of …, 2005 - Elsevier
Several recent reports have demonstrated a role for selective cannabinoid CB 2 receptor
agonists in pain modulation, showing both analgesic and antihyperalgesic activities. While the …
agonists in pain modulation, showing both analgesic and antihyperalgesic activities. While the …
A-317491, a selective P2X3/P2X2/3 receptor antagonist, reverses inflammatory mechanical hyperalgesia through action at peripheral receptors in rats
…, G Lee, S Nolan, M Niosi, MS Pearson… - European journal of …, 2004 - Elsevier
The effect of A-317491 (5-({(3-Phenoxybenzyl)[(1S)-1,2,3,4-tetrahydro-1-naphthalenyl]amino}carbonyl)-1,2,4-benzenetricarboxylic
acid), a recently described selective P2X 3 and P2X 2/…
acid), a recently described selective P2X 3 and P2X 2/…
Pharmacology of 2-[4-(4-chloro-2-fluorophenoxy) phenyl]-pyrimidine-4-carboxamide: a potent, broad-spectrum state-dependent sodium channel blocker for treating …
…, MS Pearson, L Mark, PI Turchin, S Gottshall… - … of Pharmacology and …, 2006 - ASPET
Voltage-gated Na + channels may play important roles in establishing pathological neuronal
hyperexcitability associated with chronic pain in humans. Na + channel blockers, such as …
hyperexcitability associated with chronic pain in humans. Na + channel blockers, such as …
DiPOA ([8-(3, 3-diphenyl-propyl)-4-oxo-1-phenyl-1, 3, 8-triazaspiro [4.5] dec-3-yl]-acetic acid), a novel, systemically available, and peripherally restricted Mu opioid …
GT Whiteside, JE Harrison, MS Pearson, Z Chen… - … of Pharmacology and …, 2004 - ASPET
Mu opioid receptors are expressed throughout the central and peripheral nervous systems.
Peripheral inflammation leads to an increase in mu receptor present on the peripheral …
Peripheral inflammation leads to an increase in mu receptor present on the peripheral …
[PDF][PDF] Garth T. Whiteside, James E. Harrison, Michelle S. Pearson, Zhengming Chen, Yakov Rotshteyn, Paul I. Turchin, James D. Pomonis, Lilly Mark, Katharine …
KC Brogle - THE JOURNAL OF PHARMACOLOGY AND …, 2004 - researchgate.net
Mu opioid receptors are expressed throughout the central and peripheral nervous systems.
Peripheral inflammation leads to an increase in mu receptor present on the peripheral …
Peripheral inflammation leads to an increase in mu receptor present on the peripheral …
High Genetic Diversity of Plasmodium falciparum in the Low-Transmission Setting of the Kingdom of Eswatini
…, R Gosling, S Kunene, M S. Hsiang… - The Journal of …, 2019 - academic.oup.com
Background To better understand transmission dynamics, we characterized Plasmodium
falciparum genetic diversity in Eswatini, where transmission is low and sustained by importation…
falciparum genetic diversity in Eswatini, where transmission is low and sustained by importation…
A type III effector antagonizes death receptor signalling during bacterial gut infection
Successful infection by enteric bacterial pathogens depends on the ability of the bacteria to
colonize the gut, replicate in host tissues and disseminate to other hosts. Pathogens such as …
colonize the gut, replicate in host tissues and disseminate to other hosts. Pathogens such as …
[HTML][HTML] The Type III Effectors NleE and NleB from Enteropathogenic E. coli and OspZ from Shigella Block Nuclear Translocation of NF-κB p65
HJ Newton, JS Pearson, L Badea, M Kelly… - PLoS …, 2010 - journals.plos.org
Many bacterial pathogens utilize a type III secretion system to deliver multiple effector proteins
into host cells. Here we found that the type III effectors, NleE from enteropathogenic E. coli …
into host cells. Here we found that the type III effectors, NleE from enteropathogenic E. coli …
[HTML][HTML] Do computerised clinical decision support systems for prescribing change practice? A systematic review of the literature (1990-2007)
SA Pearson, A Moxey, J Robertson, I Hains… - BMC health services …, 2009 - Springer
Background Computerised clinical decision support systems (CDSSs) are used widely to
improve quality of care and patient outcomes. This systematic review evaluated the impact of …
improve quality of care and patient outcomes. This systematic review evaluated the impact of …