To evaluate the involvement of frizzled receptors (Fzds) in oncogenesis, we investigated
mRNA expression levels of several human Fzds in more than 30 different human tumor …

Purpose: Histone deacetylase (HDAC) inhibitors have shown promising clinical activity in the
treatment of hematologic malignancies, but their activity in solid tumor indications has been …

The Chk2 kinase is a tumor suppressor and key component of the DNA damage checkpoint
response that encompasses cell cycle arrest, apoptosis, and DNA repair. It has also been …

Early cellular events associated with tumorigenesis often include loss of cell cycle checkpoints
or alteration in growth signaling pathways. Identification of novel genes involved in …

Short nucleic acid sequences specific to oncogene targets such as bcl-2, bcr-abl, and c-myc
have been shown to exhibit specific anti-cancer activity in vitro through antigene or …

The Mus81-Eme1 endonuclease is implicated in the efficient rescue of broken replication
forks in Saccharomyces cerevisiae and Schizosaccharomyces pombe. We have used gene …

The major bottleneck in gene therapy remains the issue of delivery. In this work, various
modified poly(propylene imine) (PPI) dendrimers are introduced as gene transfection agents. …

The naturally occurring cyclic tetrapeptide chlamydocin is a very potent inhibitor of cell
proliferation. Here we show that chlamydocin is a highly potent histone deacetylase (HDAC) …

TGF-β1 is a major player in chronic liver diseases promoting fibrogenesis and tumorigenesis
through various mechanisms. The expression and function of TGF-β2 have not been …

In this paper we present and discuss a novel, simple and easy to implement parametric
modeling approach to assess synergy. An extended three parameter log‐logistic model is used …