Dramatic rate accelerations of Diels-Alder reactions in 5 M lithium perchlorate-diethyl ether: the cantharidin problem reexamined
PA Grieco, JJ Nunes, MD Gaul - Journal of the American Chemical …, 1990 - ACS Publications
During the past 15 years, studies on the Diels-Alder reaction1 have produced dramatic results.
The pronounced rate enhancements and improved stereoselectivities observed to date …
The pronounced rate enhancements and improved stereoselectivities observed to date …
Fmoc mediated synthesis of peptide nucleic acids
SA Thomson, JA Josey, R Cadilla, MD Gaul… - Tetrahedron, 1995 - Elsevier
The syntheses of the Fmoc-protected Peptide Nucleic Acid (PNA) monomer pentafluorophenyl
esters of adenine (26), cytosine (23), guanine (29) and thymine (20), and their …
esters of adenine (26), cytosine (23), guanine (29) and thymine (20), and their …
Identification of diaryl ether-based ligands for estrogen-related receptor α as potential antidiabetic agents
…, JM Lenhard, MR Player, MD Gaul - Journal of medicinal …, 2011 - ACS Publications
Estrogen-related receptor α (ERRα) is an orphan nuclear receptor that has been functionally
implicated in the regulation of energy homeostasis. Herein is described the development of …
implicated in the regulation of energy homeostasis. Herein is described the development of …
[HTML][HTML] The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and-2
…, GW Caldwell, MJ Todd, Y Liang, MD Gaul… - Journal of lipid …, 2012 - ASBMB
Diacylglycerol acyltransferase (DGAT) catalyzes the final step in triglyceride (TG) synthesis.
There are two isoforms, DGAT1 and DGAT2, with distinct protein sequences and potentially …
There are two isoforms, DGAT1 and DGAT2, with distinct protein sequences and potentially …
Indazole-based ligands for estrogen-related receptor α as potential anti-diabetic agents
…, HB Askari, J Liu, J Kasturi, M Towers, MD Gaul… - European journal of …, 2017 - Elsevier
Estrogen-related receptor α (ERRα) is an orphan nuclear receptor that has been functionally
implicated in the regulation of energy homeostasis. Herein is described the development of …
implicated in the regulation of energy homeostasis. Herein is described the development of …
Enantioselective ring construction: synthesis of (+)-estrone methyl ether
DF Taber, K Raman, MD Gaul - The Journal of Organic Chemistry, 1987 - ACS Publications
The estrogenic steroids have been the target of extensive synthetic investigation, 2 both
because they are economi-cally significant and because they are among the struc-turally …
because they are economi-cally significant and because they are among the struc-turally …
Synthesis and biological evaluation of benzocyclobutane-C-glycosides as potent and orally active SGLT1/SGLT2 dual inhibitors
GH Kuo, MD Gaul, Y Liang, JZ Xu, F Du… - Bioorganic & Medicinal …, 2018 - Elsevier
… Author links open overlay panel Gee-Hong Kuo , Micheal D. Gaul , Yin Liang , June Z. Xu ,
Fuyong Du , Pamela Hornby , Guozhang Xu , Jenson Qi , Nathaniel Wallace , Seunghun Lee , …
Fuyong Du , Pamela Hornby , Guozhang Xu , Jenson Qi , Nathaniel Wallace , Seunghun Lee , …
Enantioselective construction of dialkylcarbinols: synthesis of (-)-5-hexadecanolide
DF Taber, PB Deker, MD Gaul - Journal of the American Chemical …, 1987 - ACS Publications
Alcohol 2 is designed to block one face of the carbonyls inthe derived ß-keto ester 3. Hydride
reduction can then proceed either via the transition state in which the carbonyls are syn (…
reduction can then proceed either via the transition state in which the carbonyls are syn (…
Potent sodium/glucose cotransporter SGLT1/2 dual inhibition improves glycemic control without marked gastrointestinal adaptation or colonic microbiota changes in …
…, T Kirchner, M Jennis, W Lang, GH Kuo, MD Gaul… - … of Pharmacology and …, 2018 - ASPET
The sodium/glucose cotransporters (SGLT1 and SGLT2) transport glucose across the intestinal
brush border and kidney tubule. Dual SGLT1/2 inhibition could reduce hyperglycemia …
brush border and kidney tubule. Dual SGLT1/2 inhibition could reduce hyperglycemia …
Discovery and biological evaluation of potent dual ErbB-2/EGFR tyrosine kinase inhibitors: 6-thiazolylquinazolines
MD Gaul, Y Guo, K Affleck, GS Cockerill… - Bioorganic & medicinal …, 2003 - Elsevier
We have identified a novel class of 6-thiazolylquinazolines as potent and selective inhibitors
of both ErbB-2 and EGFR tyrosine kinase activity, with IC 50 values in the nanomolar range. …
of both ErbB-2 and EGFR tyrosine kinase activity, with IC 50 values in the nanomolar range. …