AT helper cell type 1–mediated colitis develops in severe combined immunodeficient mice
after transfer of CD45RB high CD4 + T cells and can be prevented by cotransfer of the …

We have characterized the progressive stages of chronic intestinal inflammation that develops
spontaneously in specific pathogen-free (SPF) mice with a targeted disruption in the IL-10 …

We have characterized a cytokine produced by Th2 cells, designated as IL-25. Infusion of mice
with IL-25 induced IL-4, IL-5, and IL-13 gene expression. The induction of these cytokines …

CD4 + T cells in the mouse can be subdivided into two fractions based on the level of
expression of the CD45RB determinant. Previous studies have shown that these subsets are …

We have described a murine model of IBD that was induced in CB-17 scid mice by transfer
of the CD45RBhi subpopulation of CD4+ T cells from normal BALB/c mice and could be …

AT helper type 1 (Th1)-mediated colitis with similarities to inflammatory bowel disease in
humans developed in severe combined immunodeficiency mice reconstituted with CD45RB(…

Mice rendered deficient in the production of interleukin 10 (IL-10-/-) develop a chronic
inflammatory bowel disease (IBD) that predominates in the colon and shares histopathological …

Human herpesvirus 8 (HHV8, also known as Kaposi's sarcoma [KS]-associated herpesvirus)
has been implicated as an etiologic agent for KS, an angiogenic tumor composed of …

p19, a molecule structurally related to IL-6, G-CSF, and the p35 subunit of IL-12, is a subunit
of the recently discovered cytokine IL-23. Here we show that expression of p19 in multiple …

We have used interleukin-10 (IL-10) gene knockout mice (IL-10 −/− ) to examine the role of
endogenous IL-10 in allergic lung responses to Aspergillus fumigatus Ag. In vitro …