Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay
MC Alley, DA Scudiero, A Monks, ML Hursey… - Cancer research, 1988 - AACR
For the past 30 years strategies for the preclinical discovery and development of potential
anticancer agents have been based largely upon the testing of agents in mice bearing …
anticancer agents have been based largely upon the testing of agents in mice bearing …
In vivo cultivation of tumor cells in hollow fibers
MG Hollingshead, MC Alley, RF Camalier, BJ Abbott… - Life sciences, 1995 - Elsevier
Advancement of potential anti-cancer agents from “discovery” in an in vitro screen to pre-clinical
development requires a demonstration of in vivo efficacy in one or more animal models …
development requires a demonstration of in vivo efficacy in one or more animal models …
The synthesis of XTT: A new tetrazolium reagent that is bioreducible to a water‐soluble formazan
…, DA Scudiero, A Monks, MC Alley… - Journal of …, 1988 - Wiley Online Library
… Alley … С Alley, DA Scudiero, A. Monks, ML Hursey, MJ Czerwinski, DL Fine, BJ Abbott,
JG Mayo, RH Shoemaker and M. R. … С Alley, DA Scudiero, DL Fine, TL McLemore, ВJAbbott …
JG Mayo, RH Shoemaker and M. R. … С Alley, DA Scudiero, DL Fine, TL McLemore, ВJAbbott …
SJG-136 (NSC 694501), a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity: part 1 …
…, D Hochhauser, RB Pedley, LR Kelland, MC Alley… - Cancer research, 2004 - AACR
SJG-136 (NSC 694501) is a rationally designed pyrrolobenzodiazepine dimer that binds in
the minor groove of DNA. It spans 6 bp with a preference for binding to purine-GATC-…
the minor groove of DNA. It spans 6 bp with a preference for binding to purine-GATC-…
Cucurbitacin E-induced disruption of the actin and vimentin cytoskeleton in prostate carcinoma cells
KLK Duncan, MD Duncan, MC Alley… - Biochemical …, 1996 - Elsevier
Cucurbitacin E has been identified by an empiric screening strategy as a sterol with potent
growth inhibitory activity in vitro directed against prostate carcinoma explants (ic 50 of 7–50 …
growth inhibitory activity in vitro directed against prostate carcinoma explants (ic 50 of 7–50 …
Novel intrapulmonary model for orthotopic propagation of human lung cancers in athymic nude mice
TL McLemore, MC Liu, PC Blacker, M Gregg, MC Alley… - Cancer research, 1987 - AACR
A major impediment to the study of human lung cancer pathophysiology, as well as to the
discovery and development of new specific antitumor agents for the treatment of lung cancer, …
discovery and development of new specific antitumor agents for the treatment of lung cancer, …
SJG-136 (NSC 694501), a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity: part 2 …
MC Alley, MG Hollingshead, CM Pacula-Cox… - Cancer Research, 2004 - AACR
Pyrrolo[2,1-c][1,4]benzodiazepine dimer SJG-136 (NSC 694501) selectively cross-links
guanine residues located on opposite strands of DNA, and exhibits potent in vitro cytotoxicity. In …
guanine residues located on opposite strands of DNA, and exhibits potent in vitro cytotoxicity. In …
Human tumor xenograft models in NCI drug development
…, M Hollingshead, L Simpson-Herren, MC Alley - … drug development guide …, 1997 - Springer
The preclinical discovery and development of anticancer drugs by the NCI consist of a series
of test procedures, data review, and decision steps that have been summarized recently (1)…
of test procedures, data review, and decision steps that have been summarized recently (1)…
Preclinical evaluation of amino acid prodrugs of novel antitumor 2-(4-amino-3-methylphenyl) benzothiazoles
…, JA Double, I Fichtner, PA Cooper, MC Alley… - Molecular Cancer …, 2002 - AACR
Novel 2-(4-aminophenyl)benzothiazoles (eg, compounds 1 and 2) possess highly selective,
potent antitumor properties in vitro and in vivo. Elucidation of the mechanism of action of this …
potent antitumor properties in vitro and in vivo. Elucidation of the mechanism of action of this …
Aryl hydrocarbon receptor activation of an antitumor aminoflavone: basis of selective toxicity for MCF-7 breast tumor cells
…, J Boswell, M Hollingshead, MC Alley, C Hose… - Molecular cancer …, 2004 - AACR
Aminoflavone (4H-1-benzopyran-4-one, 5-amino-2-(4-amino-3-fluorophenyl)-6,8-difluoro-7-methyl;
NSC 686288) demonstrates differential antiproliferative activity in the National …
NSC 686288) demonstrates differential antiproliferative activity in the National …