Interleukin-6 as a mediator responsible for inflammation-induced increase in plasma angiotensinogen

T Masaoki, I Norio, Y Katsutoshi, Y Masako… - Biochemical …, 1993 - Elsevier
The concentration of plasma angiotensinogen increases upon induction of inflammation.
Studies were carried out using serum samples collected from mice and rats after injection of …

Angiotensin type 2 receptor–Mediated phosphorylation of eNOS in the aortas of mice with 2-Kidney, 1-Clip hypertension

H Hiyoshi, K Yayama, M Takano, H Okamoto - Hypertension, 2005 - Am Heart Assoc
To evaluate the role of vascular angiotensin II (Ang II) type 2 (AT 2 ) receptor in renovascular
hypertension, we investigated expressions of AT 2 receptor and endothelial nitric oxide …

Up-regulation of angiotensin II type 2 receptor in rat thoracic aorta by pressure-overload

K Yayama, M Horii, H Hiyoshi, M Takano… - … of Pharmacology and …, 2004 - ASPET
We have examined whether expression of angiotensin II (Ang II) type 1 (AT 1 ) and/or type 2
(AT 2 ) receptors are changed in thoracic aorta under pressure-overload by abdominal …

Proteomic analysis of the hippocampus in Alzheimer's disease model mice by using two-dimensional fluorescence difference in gel electrophoresis

M Takano, T Yamashita, K Nagano, M Otani… - Neuroscience …, 2013 - Elsevier
We previously identified the E693Δ mutation in amyloid precursor protein (APP) in patients
with Alzheimer's disease (AD) and then generated APP-transgenic mice expressing this …

Stimulation of Cyclic GMP Production via AT2 and B2 Receptors in the Pressure-Overloaded Aorta After Banding

H Hiyoshi, K Yayama, M Takano, H Okamoto - Hypertension, 2004 - Am Heart Assoc
Abdominal aortic banding induces upregulation of the angiotensin II (Ang II) type-2 (AT 2 )
receptor, thereby decreasing the contractile response to Ang II in the thoracic aorta of the rat. …

Germ cell specific protein VASA is over-expressed in epithelial ovarian cancer and disrupts DNA damage-induced G2 checkpoint

H Hashimoto, T Sudo, Y Mikami, M Otani, M Takano… - Gynecologic …, 2008 - Elsevier
OBJECTIVE: Cancer cells have characteristics, such as high telomerase activity and high
levels of migration activity and proliferation, which are very similar to those of germ cell …

Dietary deficiency of calcium and/or iron, an age-related risk factor for renal accumulation of cadmium in mice

…, H Ueda, F Sakazaki, K Yamada, M Takano… - Biological and …, 2015 - jstage.jst.go.jp
The major route of cadmium (Cd) intake by non-smokers is through food ingestion. Cd is a
non-essential metal absorbed through one or more transporters of essential metal ions. …

[HTML][HTML] Tissue kallikrein is synthesized and secreted by human vascular endothelial cells

K Yayama, N Kunimatsu, Y Teranishi, M Takano… - … et Biophysica Acta (BBA …, 2003 - Elsevier
The generation of kinins on the surface of vascular endothelium has been postulated in two
pathways involving plasma kallikrein and tissue kallikrein; the former pathway has been well …

Intracellular and nuclear bradykinin B2 receptors

M Takano, S Matsuyama - European Journal of Pharmacology, 2014 - Elsevier
Bradykinin is a vasoactive peptide that participates in numerous inflammatory processes,
vasodilation, and cell growth/survival; it mainly acts through two receptor subtypes, bradykinin …

β-Citryl-L-glutamate Acts as an Iron Carrier to Activate Aconitase Activity

…, M Narahara, M Takano… - Biological and …, 2011 - jstage.jst.go.jp
The compound b-citryl-L-glutamate (b-CG) was initially isolated from developing brains,
though its functional roles remain unclear. In in vitro experiments, the [Fe (II)(b-CG)] complex …