Adenylyl cyclase (AC) superactivation is thought to play an important role in opioid tolerance,
dependence, and withdrawal. In the present study, we investigated the involvement of …

Chronic δ-opioid receptor agonist treatment of Chinese hamster ovary (CHO) cells stably
expressing the human δ-opioid receptor (hDOR/CHO) leads to increased cAMP formation after …

An enantioselective synthesis of the CGRP antagonist BMS-846372, amenable to large scale
preparation, is presented. This new synthesis showcases a chemo- and enantioselective …

A new and efficient process to prepare di-tert-butyl (chloromethyl) phosphate, a key compound
in the formation of many phosphon-oxymethyl pro-drugs, from chloromethyl chlorosulfate (…

Conventional diamond disc pad conditioning methods employed in chemical mechanical
planarization (CMP) have presented several problems for integrated circuit (IC) manufacturers. …

Four synthetic strategies were evaluated towards the preparation of (−)-(3R,4R)-1-benzyl-4-(benzylamino)piperidin-3-ol
(1), which was constructed with control over the relative and …

A new and efficient synthesis of chloromethyl chlorosulfate (CMCS) from chloroiodomethane
and chlorosulfonic acid is described. This process leverages a chlorosulfonic acid-…

A continuously fed microfluidic chamber has been developed for determination of solution
phase diagrams for protein−precipitant systems. Laminar flow and diffusion in the chamber …

A continuously-fed crystallization chamber that allows for kinetic path control through the
crystallization phase diagram (from labile/nucleation to metastable/growth) was fabricated and …

An efficient synthetic route to the potent and selective ErbB VEGF receptor inhibitor, BMS-690514
(1) is described. Strategic modifications in both approach and procedure addressed …