Studies on bleomycin

H Umezawa, M Ishizuka, K Maeda, T Takeuchi - Cancer, 1967 - Wiley Online Library
Bleomycin A, which is a complex of water‐soluble peptides produced by a Streptomyces,
inhibits DNA synthesis in intact cells of E. coli and HeLa cells and also inhibits Ehrlich …

Tetrahydropyranyl derivatives of daunomycin and adriamycin

…, H NAGANAWA, T MASUDA, M ISHIZUKA… - The Journal of …, 1979 - jstage.jst.go.jp
… HAMAO UMEZAWA YOSHIKAZU TAKAHASHI MITSUHIRO KINOSHITA* HIROSHI
NAGANAWA TORU MASUDA MASAAKI ISHIZUKA KUNIAKI TATSUTA* TOMIO TAKEUCHI …

Biological activities of leupeptins

…, M Nanbo, F Kojima, M Matsuzaki, M Ishizuka… - The Journal of …, 1969 - jstage.jst.go.jp
Materials and Methods Humanplasminogen: Euglobulin fraction containing plasminogen
was prepared from human serumby the method described by Kline4) and Norman5). It was …

Neothramycins A and B, new antitumor antibiotics

T Takeuchi, M MIYAMOTO, M ISHIZUKA… - The Journal of …, 1976 - jstage.jst.go.jp
These antibiotics in the filtrate were adsorbed on activated carbon and eluted with 50
aqueous acetone at pH 8.0 (adjusted with aqueous ammonia) and also by extraction from the …

New antitumor antibiotics, aclacinomycins A and B

…, A TAKAMATSU, H UMEZAWA, M ISHIZUKA… - The Journal of …, 1975 - jstage.jst.go.jp
In an example, the cultured broth (pH 7.4) which contained 32 mcg/ml of aclacinomycin A
and 23 mcg/ml of aclacinomycin B was adjusted to pH 4.5 and filtered. Aclacinomycins were …

A new antitumor antibiotic, spergualin: isolation and antitumor activity

…, S KUNIMOTO, T MASUDA, M ISHIZUKA… - The Journal of …, 1981 - jstage.jst.go.jp
Sir: In testing the activity of culture filtrates to inhibit focus formation of chicken fibroblasts by
Rous sarcoma virus, an antibiotic produced by a bacillus isolated from a soil sample …

Isolation and biological activity of a novel cytokine modulator, cytoxazone

…, K Kobinata, M Osono, M Ishizuka… - The Journal of …, 1998 - jstage.jst.go.jp
shown to associate with pathophysiologic disorders observed in atopic patients, including patients
with atopic dermatitis, whose Page 1 VOL. 51, NO. 12, DEC. 1998 THE JOURNAL OF …

Marinactan, antitumor polysaccharide produced by marine bacteria

…, S KURASAWA, T OHNUKI, M ISHIZUKA… - The Journal of …, 1983 - jstage.jst.go.jp
Positive without gas formation; D-glucose, D-xylose, maltose, sucrose, cellobiose and
rhamnose. Negative without gas formation; L-arabinose, D-mannose, D-fructose, D-galactose, …

Bisucaberin, a new siderophore, sensitizing tumor cells to macrophage-mediated cytolysis I. taxonomy of the producing organism, isolation and biological properties

…, A TAKAHASHI, S KURASAWA, M ISHIZUKA… - The Journal of …, 1987 - jstage.jst.go.jp
Fibrosarcoma 1023, a tumorigenic tumor cell line was kindly donated by Dr. T. Tokunaga,
National Institute of Health, Tokyo, Japan. This cell line had been induced in a C3H/HeNicr …

Studies on the mechanism of antitumor effect of bleomycin on squamous cell carcinoma

…, S HORI, T SAWA, M ISHIZUKA… - The Journal of …, 1972 - jstage.jst.go.jp
Materials and Methods 3H-Bleomycins: Bleomycin A2 and bleomycin mixture which were
prepared by Nipponkayaku Co. weretritiated and purified by CM-Sephadex chromatography …