User profiles for Maryellen F. Eckenhoff

Maryellen Fazen Eckenhoff

University of Pennsylvania Perelman School of Medicine
Verified email at uphs.upenn.edu
Cited by 5337

Concurrent overproduction of synapses in diverse regions of the primate cerebral cortex

P Rakic, JP Bourgeois, MF Eckenhoff, N Zecevic… - Science, 1986 - science.org
Synapses develop concurrently and at identical rates in different layers of the visual,
somatosensory, motor, and prefrontal areas of the primate cerebral cortex. This isochronic course of …

Inhaled anesthetic enhancement of amyloid-β oligomerization and cytotoxicity

RG Eckenhoff, JS Johansson, H Wei… - The Journal of the …, 2004 - pubs.asahq.org
Background The majority of surgical patients receive inhaled anesthetics, principally small
haloalkanes and haloethers. Long-term cognitive problems occur in the elderly subsequent to …

Brain and behavior changes in 12-month-old Tg2576 and nontransgenic mice exposed to anesthetics

…, S Lin, Y Li, JM Keller, RG Eckenhoff, MF Eckenhoff - Neurobiology of …, 2008 - Elsevier
Inhaled anesthetics have been shown to increase the aggregation of amyloid beta in vitro
through the stabilization of intermediate toxic oligomers, which are thought to contribute to …

Human Alzheimer and inflammation biomarkers after anesthesia and surgery

…, LM Shaw, MF Eckenhoff, RG Eckenhoff - The Journal of the …, 2011 - pubs.asahq.org
Background The prevalence of postoperative cognitive disturbance, coupled with growing
in vitro, cell, and animal evidence suggesting anesthetic effects on neurodegeneration, calls …

Nature and fate of proliferative cells in the hippocampal dentate gyrus during the life span of the rhesus monkey

MF Eckenhoff, P Rakic - Journal of Neuroscience, 1988 - Soc Neuroscience
The nature of proliferative cells in the subgranular zone (SGZ) of the hippocampal region
and the fate of their progeny was analyzed by 3H- thymidine (3H-TdR) autoradiography …

Radial organization of the hippocampal dentate gyrus: a Golgi, ultrastructural, and immunocytochemical analysis in the developing rhesus monkey

MF Eckenhoff, P Rakic - Journal of comparative neurology, 1984 - Wiley Online Library
The cytoarchitectonic organization of the dentate gyrus was analyzed in the rhesus monkey
at various embryonic (E) and postnatal (P) ages with the rapid Golgi method, transmission …

Perioperative neurocognitive disorder: state of the preclinical science

RG Eckenhoff, M Maze, Z Xie, DJ Culley… - …, 2020 - pubs.asahq.org
The purpose of this article is to provide a succinct summary of the different experimental
approaches that have been used in preclinical postoperative cognitive dysfunction research, …

Dantrolene ameliorates cognitive decline and neuropathology in Alzheimer triple transgenic mice

…, Z Wu, DJ Joseph, Q Meng, Y Peng, MF Eckenhoff… - Neuroscience …, 2012 - Elsevier
Disruption of intracellular calcium homeostasis via abnormal and excessive activation of
ryanodine receptors plays an important role in the neuropathology of Alzheimer's disease. We …

Consensus statement: first international workshop on anesthetics and Alzheimer's disease

…, DJ Culley, MF Eckenhoff, RG Eckenhoff… - Anesthesia & …, 2009 - journals.lww.com
IMPLICATIONS This article is a consensus view on the possible link between Alzheimer’s
disease and anesthesia and the steps required to test this more definitively. From the* …

A quantitative analysis of synaptogenesis in the molecular layer of the dentate gyrus in the rhesus monkey

MF Eckenhoff, P Rakic - Developmental Brain Research, 1991 - Elsevier
Quantitative electron microscopy was used to study synapse formation in the molecular
layer of the dentate gyrus in rhesus monkeys ranging in age from embryonic day 62 to adult. …