G tions between drugs and proteins, which was published in 1949, surveyed and summarized
a rather large literature and, in addition, clearly and lucidly emphasized the potential …

The bioavailability of three lots of a generic 200-mg carbamazepine tablet, which had been
withdrawn from the market, was compared to the bioavailability of one lot of the innovator …

Genetic polymorphisms in the cytochrome P450 (CYP) family are widely known to contribute
to interindividual differences in the pharmacokinetics of many drugs. Several alleles for the …

The objective of this work is to use an artificial neural network (ANN) and pharmacokinetic
simulations in the design of controlled-release formulations with predictable in vitro and in …

A crossover study in 18 subjects evaluated the plasma concentration–time profile of two
different 20 mg sustained‐release (SR) methylphenidate (MPH) tablets administered before …

Purpose. To determine if changes in the in vitrodissolution of hard and soft gelatin
acetaminophen capsules, which resultfrom gelatin crosslinking, are predictive of changes in the …

5-Aminolevulinic acid (ALA) is a precursor of protoporphyrin IX (PpIX) that is being evaluated
for use in photodiagnosis and phototherapy of malignant and nonmalignant disorders. …

Purpose. To determine if three marketed generic carbamazepine tablets were bioequivalent
to the innovator formulation, as well as to each other. In addition, to examine in vivo-in vitro …

The purpose of these studies was to examine the pharmacokinetics, oral bioavailability, and
systemic side effects of aminolevulinic acid (ALA) in beagle dogs after oral and iv …

As generic products become more available for the treatment of psychiatric disorders, clinicians
must stay abreast of the US Food and Drug Administration (FDA) requirements for the …