Pioglitazone increases insulin sensitivity, reduces blood glucose, insulin, and lipid levels, and lowers blood pressure, in obese, insulin-resistant rhesus monkeys
…, ST Baum, RN Bergman, MD Meglasson - Diabetes, 1994 - Am Diabetes Assoc
The antidiabetic effects of pioglitazone hydrochloride were evaluated in 6 spontaneously
obese, insulin-resistant rhesus monkeys. The animals were studied during six successive 2-wk …
obese, insulin-resistant rhesus monkeys. The animals were studied during six successive 2-wk …
Energy metabolism in islets of Langerhans
…, J Bryła, M Michalik, MD Meglasson, D Nelson - … et Biophysica Acta (BBA …, 1992 - Elsevier
… For this reason rathcr than expressing data on the basis of the number ot islets it is
preferable to do so in teems of either DNA. protein or dry weight content. … In pcrifusions in …
preferable to do so in teems of either DNA. protein or dry weight content. … In pcrifusions in …
Synthesis and biological activity of analogues of the antidiabetic/antiobesity agent 3-guanidinopropionic acid: discovery of a novel aminoguanidinoacetic acid …
…, BR Evans, PD May, MD Meglasson… - Journal of medicinal …, 2001 - ACS Publications
3-Guanidinopropionic acid (1, PNU-10483) has been demonstrated to both improve insulin
sensitivity and to promote weight loss selectively from adipose tissue in animal models of non…
sensitivity and to promote weight loss selectively from adipose tissue in animal models of non…
Synthesis and biological activity of aminoguanidine and diaminoguanidine analogues of the antidiabetic/antiobesity agent 3-guanidinopropionic acid
…, PV Fisher, PD May, MD Meglasson… - Journal of medicinal …, 2001 - ACS Publications
3-Guanidinopropionic acid (1) has been demonstrated both to improve insulin sensitivity
and to promote weight loss selectively from adipose tissue in animal models of non-insulin-…
and to promote weight loss selectively from adipose tissue in animal models of non-insulin-…
Chromatographic resolution and kinetic characterization of glucokinase from islets of Langerhans.
MD Meglasson, PT Burch, DK Berner… - Proceedings of the …, 1983 - National Acad Sciences
Glucokinase (ATP:D-glucose 6-phosphotransferase, EC 2.7.1.2) from rat islets of Langerhans
was partially purified by chromatography on DEAE-Cibacron blue F3GA agarose. The …
was partially purified by chromatography on DEAE-Cibacron blue F3GA agarose. The …
Effect of Ca++ channel blockers on energy level and stimulated insulin secretion in isolated rat islets of Langerhans.
M Ohta, J Nelson, D Nelson, MD Meglasson… - … of Pharmacology and …, 1993 - ASPET
To investigate the effect of calcium channel blockade on intracellular energy levels and
stimulated insulin secretion in isolated rat pancreatic islets, five different blockers of calcium …
stimulated insulin secretion in isolated rat pancreatic islets, five different blockers of calcium …
[PDF][PDF] Antihyperglycemic Action of Guanidinoalkanoic Acids: 3-Guanidinopropionic Acid Ameliorates Hyperglycemia in Diabetic KKA^ y and C57BL6J ob/ob Mice and …
MD Meglasson, JM Wilson, JH Yu… - … of Pharmacology and …, 1993 - Citeseer
To evaluate the long-held concept that acidic guanidines lack glycemic effects, guanidinoalkanoic
acids and the biguanide met-formin (positive control) were administered to KKA mice, …
acids and the biguanide met-formin (positive control) were administered to KKA mice, …
Pharmacokinetics and pharmacodynamics of LGD-3303 [9-chloro-2-ethyl-1-methyl-3-(2, 2, 2-trifluoroethyl)-3H-pyrrolo-[3, 2-f] quinolin-7 (6H)-one], an orally available …
…, KJ Lee, Z O'Brien, WY Chang, MD Meglasson… - … of Pharmacology and …, 2009 - ASPET
Selective androgen receptor modulators (SARMs) are a new class of molecules in
development to treat a variety of diseases. SARMs maintain the beneficial effects of androgens, …
development to treat a variety of diseases. SARMs maintain the beneficial effects of androgens, …
Progesterone inhibits insulin secretion by a membrane delimited, non-genomic action
SG Straub, GWG Sharp, MD Meglasson… - Bioscience …, 2001 - portlandpress.com
In rat islets, progesterone caused a prompt concentration-dependent inhibition of glucose-stimulated
insulin release with an IC50 of 10 μM at 8.4 mM glucose. The inhibition was …
insulin release with an IC50 of 10 μM at 8.4 mM glucose. The inhibition was …
Identification of polymorphisms associated with hypertriglyceridemia and prolonged survival induced by bexarotene in treating non-small cell lung cancer
…, A Negro-Vilar, MD Meglasson - Anticancer …, 2011 - ar.iiarjournals.org
Background: Bexarotene was evaluated in treating advanced non small cell lung cancer (NSCLC)
in two phase III trials. Although a significant survival benefit was not observed for the …
in two phase III trials. Although a significant survival benefit was not observed for the …