Emerging evidence suggests that inflammation provides a link between obesity and insulin
resistance. The noncanonical IκB kinases IKK-ɛ and TANK-binding kinase 1 (TBK1) are …

Described in this report is a successful cloning and characterization of a functionally active
Drosophila sulfakinin receptor designated DSK-R1. When expressed in mammalian cells, …

Regulators of G protein signaling (RGS) proteins are potent negative modulators of G
protein signaling and have been proposed as potential targets for small-molecule inhibitor …

Furin is a ubiquitously expressed proprotein convertase (PC) that plays a vital role in numerous
disease processes including cancer metastasis, bacterial toxin activation (eg anthrax …

Natural variations of wild Caenorhabditis elegans isolates having either Phe-215 or Val-215
in NPR-1, a putative orphan neuropeptide Y-like G protein-coupled receptor, result in either "…

Members of the heat shock protein 70 (Hsp70) family of molecular chaperones are emerging
as potential therapeutic targets. Their ATPase activity has classically been measured using …

The widespread occurrence of antibiotic resistance among human pathogens is a major
public health problem. Conventional antibiotics typically target bacterial killing or growth …

microRNAs (miRNAs) are small gene regulatory RNAs, and their expression has been
found to be dysregulated in a number of human diseases. To facilitate the discovery of small …

Despite advances toward understanding the prevention and treatment of many cancers,
patients who suffer from oral squamous cell carcinoma (OSCC) confront a survival rate that has …

The type-A allatostatins A (AST-A) are a group of insect peptides with a common C-terminal
motif Y/FXFGL-NH 2 . The existence of at least four putative type A Drosophila melanogaster …