Ten years ago, a consensus report on the optimization of tacrolimus was published in this
journal. In 2017, the Immunosuppressive Drugs Scientific Committee of the International …

Mycophenolate mofetil (MMF) is almost completely absorbed from the gut and is rapidly de-esterified
into its active drug, mycophenolic acid (MPA). The main metabolite is …

When mycophenolic acid (MPA) was originally marketed for immunosuppressive therapy,
fixed doses were recommended by the manufacturer. Awareness of the potential for a more …

In 2014, the Immunosuppressive Drugs Scientific Committee of the International Association
of Therapeutic Drug Monitoring and Clinical Toxicology called a meeting of international …

Aims Heart transplantation may represent a particular risk factor for severe coronavirus
infectious disease 2019 (COVID-19) due to chronic immunosuppression and frequent …

With current treatment regimens, a relatively high proportion of transplant recipients experience
underimmunosuppression or overimmunosuppression. Recently, several promising …

The shortage of appropriate donor organs and the expanding pool of patients waiting for
heart transplantation have led to growing interest in alternative strategies, particularly in …

Donor-specific antibodies (DSA) are integral to the development of antibody-mediated rejection
(AMR). Chronic AMR is associated with high mortality and an increased risk for cardiac …

Objectives: Acute uncomplicated Stanford type B aortic dissection (TBAD) is optimally
managed with medical treatment. However, surgery and thoracic endovascular aortic repair (…

Purpose Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) stabilizes patients
in refractory cardiogenic shock. However, ECMO-related complications strongly affect the …