Animals must balance their energy budget despite seasonal changes in both energy availability
and physiological expenditures. Immunity, in addition to growth, thermoregulation, and …

Erythropoietin (EPO), well known for its role in stimulation of erythropoiesis, has recently
been shown to have a dramatic neuroprotective effect in animal models of cerebral ischemia, …

Sirt1 is an NAD+-dependent deacetylase that extends lifespan in lower organisms and
improves metabolism and delays the onset of age-related diseases in mammals. Here we show …

Submaximal and maximal oxygen consumption was determined in untrained adult and
aged male C57BL/6J mice during treadmill running. Each of 12-month-old (ADULT) and 24-…

Background. We have reported that β 2 adrenoreceptor (β 2 AR) stimulation is anti-apoptotic,
and has strong beneficial effect on cardiac remodeling in an experimental model of post …

The main clinical manifestations of advanced chronic heart failure (CHF), eg in dilated
cardiomyopathy (DCM), are reduced systolic and diastolic functions, increased arterial elastance …

Background— Digitalis-like sodium pump ligands (SPLs) effect natriuresis via inhibition of
renal tubular Na + ,K + -ATPase but may induce vasoconstriction. The present study …

Background— Studies in isolated cardiac myocytes have demonstrated that signaling via
specific β 1 -adrenergic receptor subtypes (β 1 ARs) promotes but that signaling via β 2 ARs …

Multiple health benefits of calorie restriction (CR) and alternate day fasting (ADF) regimens
are widely recognized. Experimental data concerning the effects of calorie restriction on …

The ability to create experimental myocardial infarctions of reproducible size and location is
tantamount to progress in multiple facets of ischemic heart disease research. Branches of …