The cysteinyl leukotrienes (CysLTs) mimic many of the features of asthma and are implicated
in its pathophysiology. Little, however, is known about the effects of the CysLTs on airways …

In the present study phosphodiesterase (PDE) isozymes in human airway smooth muscle
were isolated, identified and characterized, and the functional roles of these isozymes in intact …

Activation of muscarinic subtype 3 (M3) muscarinic cholinergic receptors (mAChRs) increases
airway tone, whereas its blockade improves lung function and quality of life in patients …

Prior studies have demonstrated that the ion channel transient receptor potential vanilloid 4 (TRPV4)
is functionally expressed in airway smooth muscle cells and that TRPV4 single …

The role of endothelin B (ET B ) receptors in inflammation and nociception was examined
using ET B receptor knockout mice. Genotyping studies were used with tissues from ET B (+/+) …

The potent bronchoconstrictor and mitogenic actions of the peptide endothelin-1 (ET-1) on
airway smooth muscle may contribute significantly to the bronchial obstruction observed in …

Selective inhibition of phosphodiesterase (PDE) isozymes has been shown to inhibit
inflammatory cell function and relax airway smooth muscle and, thus, may be useful in the therapy …

The pharmacological and pharmacokinetic profile of SB-222200 [(S)-(−)-N-(α-ethylbenzyl)-3-methyl-2-phenylquinoline-4-carboxamide],
a human NK-3 receptor (hNK-3R) antagonist, …

Revefenacin ( TD ‐4208) is a novel, long‐acting, and lung‐selective muscarinic cholinergic
receptor ( mAChR ) antagonist in development as a nebulized inhalation solution for the …

In this report the in vitro and in vivo pharmacological and pharmacokinetic profile of (−)-(S)-N-(α-ethylbenzyl)-3-(carboxymethoxy)-2-phenylquinoline-4-carboxamide
(SB 235375), a low …