The effects of the antiestrogen tamoxifen (TAM) on the growth of two hormone-sensitive
human tumors have been examined in athymic mice. The endometrial tumor, EnCa101, was …

Long-term tamoxifen (TAM) therapy was examined in athymic mice bearing MCF-7 tumors of
different sizes. Six months of TAM treatment caused no increase in tumor size (compared to …

The effects of cadmium on estrogen receptor and other estrogen-regulated genes in the
human breast cancer cell line MCF-7 were studied. Treatment of MCF-7 cells with 1 microM …

We have compared the antitumor activities of the antiestrogens, keoxifene (LY 156758) and
tamoxifen (TAM), using the N-nitrosomethylurea (NMU) rat mammary carcinoma model. To …

Epidemiologic studies suggest that type 2 diabetes (T2D) increases breast cancer risk and
mortality, but there is limited experimental evidence supporting this association. Moreover, …

BMS-754807 is a potent and reversible inhibitor of the insulin-like growth factor 1 receptor/insulin
receptor family kinases (Ki, <2 nmol/L). It is currently in phase I development for the …

Type I insulin-like growth factor receptor (IGF-IR) can transform mouse fibroblasts; however,
little is known about the transforming potential of IGF-IR in human fibroblasts or epithelial …

We have examined several types of tumor cell lines and shown that they invariably expressed
little or no Egr‐1, in contrast to their normal counterparts. We have previously shown that …

The understanding of the key role that androgens play on the normal and pathological
physiology of the prostate guided the development of different therapies for the treatment of …

Uterine myometrial tumors are the most commonly found gynecological neoplasm in women.
The underlying causes of uterine leiomyomata are poorly understood, a result in part of the …