Serotonin (5-hydroxytryptamine, 5-HT) is an important modulatory neurotransmitter and
functions as a key neurodevelopmental signal in the mammalian brain. 5-HT plays a prominent …

BACKGROUND: Impulsive decision making, apparent as intolerance for reinforcement delay,
is prominent in attention-deficit/hyperactivity disorder. Commonly prescribed for this …

Differences in locomotor activity, exploratory activity and anxiety-like behaviour of C57BL/6ChR,C57BL/6J,
Swiss Webster/J and A/J strain were investigated in an anxiety battery. The …

Rationale Behavioral disinhibition is a manifestation of impulsive behavior that is prominent
in the psychopathology of various psychiatric disorders, but the underlying neural …

Rationale Impaired inhibitory control over behavior is a key feature in various psychiatric
disorders, and recent studies indicated an important role for dopamine D 1 and D 2 receptors …

Antidepressant drug treatment is the clinical standard of care for all types of anxiety disorders.
Broad efficacy of selective serotonin reuptake inhibitors suggests the importance of …

One major hallmark of Alzheimer's disease (AD) is the massive loss of synapses that occurs
at an early clinical stage of the disease. In this study, we characterize alterations in spine …

Central administration of corticotropin‐releasing hormone increases anxiety‐like behaviour
and arousal in rodents, and increased anxiety‐like behaviour has been shown in mice …

Oligomers of the β-amyloid (Aβ) peptide have been indicated in early neuropathologic
changes in Alzheimer's disease. Here, we present a synthetic Aβ 20-42 oligomer (named …

A neuropsychological hallmark of attention deficit/hyperactivity disorder (ADHD) is the reduced
ability to tolerate delay of reinforcement, leading to impulsive choice. Genetic association …