Filamentous tau inclusions are hallmarks of Alzheimer's disease (AD) and related tauopathies,
but earlier pathologies may herald disease onset. To investigate this, we studied wild-…

Alpha-synuclein (α-syn) and tau polymerize into amyloid fibrils and form intraneuronal
filamentous inclusions characteristic of neurodegenerative diseases. We demonstrate that α-syn …

Formation of senile plaques composed of amyloid β peptide, a pathological hallmark of
Alzheimer disease, in human brains precedes disease onset by many years. Noninvasive …

Diverse neurodegenerative disorders are characterized by deposition of tau fibrils composed
of conformers (ie strains) unique to each illness. The development of tau imaging agents …

Expression of somatostatin in the brain declines during aging in various mammals including
apes and humans 1 , 2 . A prominent decrease in this neuropeptide also represents a …

We provide the first evidence for the capability of a high-resolution positron emission
tomographic (PET) imaging system in quantitatively mapping amyloid accumulation in living …

Accumulation of intracellular tau fibrils has been the focus of research on the mechanisms
of neurodegeneration in Alzheimer's disease (AD) and related tauopathies. Here, we have …

Elucidating the neural and genetic factors underlying psychiatric illness is hampered by
current methods of clinical diagnosis. The identification and investigation of clinical …

A panel of radiochemicals has enabled in vivo positron emission tomography (PET) of tau
pathologies in Alzheimer's disease (AD), although sensitive detection of frontotemporal lobar …

The accumulation of amyloid-β peptide (Aβ), a physiological peptide, in the brain is a triggering
event leading to the pathological cascade of Alzheimer's disease (AD) and appears to be …