Human and animal studies indicate that κ-opioid receptors (KORs) are involved in ethanol
drinking and dependence ( Xuei et al., 2006 ; Walker and Koob, 2008 ; Walker et al., 2011 ). …

The corticotropin-releasing factor (CRF) and kappa-opioid receptor (KOR) systems are both
implicated in stress-related behaviors and drug dependence. Although previous studies …

Background: Intermittent chronic administration of ethanol to rats has been shown previously
to produce a hyperexcitable, kindling‐like state, accompanied by reduced inhibitory …

We have previously reported that varying stimulus intensity produces qualitatively different
types of synaptic plasticity in area CA1 of hippocampal slices: brief low-intensity (LI) theta-…

The impairment of learning and memory is one of the most powerful and least understood
effects of marijuana although the hippocampal formation appears to be one CNS region …

Endogenous opioid systems are implicated in the reinforcing effects of ethanol consumption.
For example, δ opioid receptor (DOR) knockout (KO) mice show greater ethanol …

Endogenous opioid systems are implicated in the actions of ethanol. For example, μ-opioid
receptor (MOR) knockout (KO) mice self-administer less alcohol than the genetically intact …

Studies have revealed that the amygdala formation is involved in emotional learning, attention,
and autonomic functions. Although intra-amygdala connections have been described …

The central nucleus of the amygdala (CeA) plays a critical role in regulating the behavioral,
autonomic and endocrine response to stress. Dopamine (DA) participates in mediating the …

Adolescent intermittent ethanol (AIE) exposure compromises neural function into adulthood.
We have reported that astrocyte-secreted thrombospondins, and their target neuronal …