Oxidative conversion of all-trans-retinol (t-ROH) to all-trans-retinal (t-RAL) is recognized as
the rate-limiting step for biosynthesis of all-trans-retinoic acid fromt-ROH in mammalian …

… and MR Juchau, The in vitro teratogenicity of cyclophosphamide in rat embryos, Teru- … R.
Juchau, Cytochrome P450dependent biotransformation of a series of phenoxazone ethers in …

Although much is known about the metabolism of environmental toxicants in adult organisms,
little information exists on the role of cytochrome P450 (CYP) enzymes during development…

Because polynuclear aromatic hydrocarbons (PAHs) appear to be the most prevalent of the
environmental contaminants [l] and because of the pronounced carcinogenicity of many of …

Expression of functional cytochrome P450 (CYP) isoforms in human embryonic tissues was
explored during organogenesis (days 50-60 of gestation) with substrate probes, inhibitor …

Day 10 rat embryos grown as cultured explants in vitro developed characteristic defects
when culture media contained cyclophosphamide (6.25 micrograms per milliliter or more), an …

Cytochrome P-450 2E1 (CYP2E1) is a readily inducible hemoprotein that catalyzes the
oxidation of endogenous compounds and many low molecular weight xenobiotics. As the major …

Cytochrome P4503A7 (CYP3A7) is the primary CYP isoform expressed in human fetal
hepatic microsomes, and its potential role in human embryotoxicity has attracted considerable …

Investigations with chemical inhibitors and with inhibitory antibodies specific for cytochrome
P4501A-catalyzed ethoxyresorufin (ethoxyphenoxazone) O-deethylation and 2-…

The perinatal period has been recognized as an identifiable area of pharmacological endeavor
by reviews in Volumes 8, 10, and 12 of this series (1-3) and in Volumes 17 and 24 of the …